Association of Isolated Congenital Heart Disease with Fetal Brain Maturation.

Adult Brain / abnormalities Female Fetus / diagnostic imaging Heart Defects, Congenital / complications Humans Image Interpretation, Computer-Assisted / methods Infant, Newborn Magnetic Resonance Imaging / methods Male Pregnancy Prenatal Diagnosis / methods Prospective Studies Reproducibility of Results

Journal

AJNR. American journal of neuroradiology
ISSN: 1936-959X
Titre abrégé: AJNR Am J Neuroradiol
Pays: United States
ID NLM: 8003708

Informations de publication

Date de publication:
08 2020
Historique:
received: 03 12 2019
accepted: 30 04 2020
pubmed: 11 7 2020
medline: 29 12 2020
entrez: 11 7 2020
Statut: ppublish

Résumé

Brain MRI of newborns with congenital heart disease show signs of immaturity relative to healthy controls. Our aim was to determine whether the semiquantitative fetal total maturation score can detect abnormalities in brain maturation in fetuses with congenital heart disease in the second and third trimesters. We analyzed data from a prospective study of fetuses with and without congenital heart disease who underwent fetal MR imaging at 25-35 weeks' gestation. Two independent neuroradiologists blinded to the clinical data reviewed and scored all images using the fetal total maturation score. Interrater reliability was evaluated by the intraclass correlation coefficient using the individual reader scores, which were also used to calculate an average score for each subject. Comparisons of the average and individual reader scores between affected and control fetuses and relationships with clinical variables were evaluated using multivariable linear regression. Data from 69 subjects (48 cardiac, 21 controls) were included. High concordance was observed between readers with an intraclass correlation coefficient of 0.98 (95% CI, 0.97-0.99). The affected group had significantly lower fetal total maturation scores than the control group ( The fetal total maturation score is sensitive to differences in brain maturation between fetuses with isolated congenital heart disease and healthy controls.

Sections du résumé

BACKGROUND AND PURPOSE
Brain MRI of newborns with congenital heart disease show signs of immaturity relative to healthy controls. Our aim was to determine whether the semiquantitative fetal total maturation score can detect abnormalities in brain maturation in fetuses with congenital heart disease in the second and third trimesters.
MATERIALS AND METHODS
We analyzed data from a prospective study of fetuses with and without congenital heart disease who underwent fetal MR imaging at 25-35 weeks' gestation. Two independent neuroradiologists blinded to the clinical data reviewed and scored all images using the fetal total maturation score. Interrater reliability was evaluated by the intraclass correlation coefficient using the individual reader scores, which were also used to calculate an average score for each subject. Comparisons of the average and individual reader scores between affected and control fetuses and relationships with clinical variables were evaluated using multivariable linear regression.
RESULTS
Data from 69 subjects (48 cardiac, 21 controls) were included. High concordance was observed between readers with an intraclass correlation coefficient of 0.98 (95% CI, 0.97-0.99). The affected group had significantly lower fetal total maturation scores than the control group (
CONCLUSIONS
The fetal total maturation score is sensitive to differences in brain maturation between fetuses with isolated congenital heart disease and healthy controls.

Identifiants

DOI: 10.3174/ajnr.A6635 PMID: 32646947 PMC: PMC7658885
pubmed: 32646947
pii: ajnr.A6635
doi: 10.3174/ajnr.A6635
pmc: PMC7658885
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1525-1531

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS106030
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL141602
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB018988
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS101120
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB013248
Pays : United States

Informations de copyright

© 2020 by American Journal of Neuroradiology.

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Auteurs

C Jaimes (C)

From the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.
Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Pediatrics (K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Harvard Medical School, Boston, Massachusetts.
ORCID: 0000-0002-7169-4244

V Rofeberg (V)

From the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.
ORCID: 0000-0002-0053-1536

C Stopp (C)

From the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.
ORCID: 0000-0002-6360-5993

C M Ortinau (CM)

Pediatrics (C.M.O.), Washington University in St. Louis, St. Louis, Missouri.
ORCID: 0000-0003-0851-0796

A Gholipour (A)

From the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.
Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Pediatrics (K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Harvard Medical School, Boston, Massachusetts.
ORCID: 0000-0001-7699-4564

K G Friedman (KG)

From the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.
Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Pediatrics (K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Harvard Medical School, Boston, Massachusetts.
ORCID: 0000-0002-3180-9764

W Tworetzky (W)

From the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.
Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Pediatrics (K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Harvard Medical School, Boston, Massachusetts.
ORCID: 0000-0002-8422-2158

J Estroff (J)

From the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.
Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Pediatrics (K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Harvard Medical School, Boston, Massachusetts.
ORCID: 0000-0002-4578-2531

J W Newburger (JW)

From the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.
Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Pediatrics (K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Harvard Medical School, Boston, Massachusetts.
ORCID: 0000-0002-7794-9017

D Wypij (D)

From the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.
Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Pediatrics (K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Harvard Medical School, Boston, Massachusetts.
Biostatistics (D.W.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
ORCID: 0000-0001-8367-8711

S K Warfield (SK)

From the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.
Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Pediatrics (K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Harvard Medical School, Boston, Massachusetts.
ORCID: 0000-0002-7659-3880

E Yang (E)

From the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.
Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Pediatrics (K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Harvard Medical School, Boston, Massachusetts.
ORCID: 0000-0002-9912-4163

C K Rollins (CK)

From the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts caitlin.rollins@childrens.harvard.edu.
Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Pediatrics (K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Harvard Medical School, Boston, Massachusetts.
ORCID: 0000-0002-0500-0056

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Association of Isolated Congenital Heart...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Association of Isolated Congenital Heart...
questionsmedicales.fr › Structures de l'embryon › Foetus › Association of Isolated Congenital Heart...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations cardiovasculaires › Cardiopathies congénitales › Association of Isolated Congenital Heart...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of Isolated Congenital Heart...
questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Prise de décision assistée par ordinateur › Diagnostic assisté par ordinateur › Interprétation d'images assistée par ordinateur › Association of Isolated Congenital Heart...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Association of Isolated Congenital Heart...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Association of Isolated Congenital Heart...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Association of Isolated Congenital Heart...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic gynécologique et obstétrique › Diagnostic prénatal › Association of Isolated Congenital Heart...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Association of Isolated Congenital Heart...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Association of Isolated Congenital Heart...