NOXA upregulation by the prohibitin-binding compound fluorizoline is transcriptionally regulated by integrated stress response-induced ATF3 and ATF4.
Activating Transcription Factor 3
/ genetics
Activating Transcription Factor 4
/ genetics
Apoptosis
/ drug effects
Biphenyl Compounds
/ pharmacology
Cell Line, Tumor
Drug Synergism
Gene Expression Regulation, Neoplastic
/ drug effects
HeLa Cells
Humans
Hydrocarbons, Fluorinated
/ metabolism
Nitrophenols
/ pharmacology
Piperazines
/ pharmacology
Prohibitins
Protein Binding
Proto-Oncogene Proteins c-bcl-2
/ genetics
Repressor Proteins
/ genetics
Reverse Transcriptase Polymerase Chain Reaction
Sulfonamides
/ pharmacology
Thiazoles
/ metabolism
Transcriptional Activation
/ drug effects
Up-Regulation
/ drug effects
ATF
ISR
NOXA
apoptosis
fluorizoline
prohibitins
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
27
02
2020
revised:
17
06
2020
accepted:
30
06
2020
pubmed:
11
7
2020
medline:
27
7
2021
entrez:
11
7
2020
Statut:
ppublish
Résumé
Fluorizoline is a new synthetic molecule that induces p53-independent apoptosis, in several tumor cell lines and in primary leukemia cells, by selectively targeting prohibitins (PHBs). In this study, we describe how fluorizoline induces BCL-2 homology 3-only protein NOXA, without modulating the protein levels of anti-apoptotic B-cell lymphoma-2 (BCL-2) family members prior to caspase activation, as well as how it synergizes with the BCL-2 and BCL-X
Substances chimiques
ABT-737
0
ATF3 protein, human
0
ATF4 protein, human
0
Activating Transcription Factor 3
0
Biphenyl Compounds
0
Hydrocarbons, Fluorinated
0
Nitrophenols
0
PHB protein, human
0
PMAIP1 protein, human
0
Piperazines
0
Prohibitins
0
Proto-Oncogene Proteins c-bcl-2
0
Repressor Proteins
0
Sulfonamides
0
Thiazoles
0
Activating Transcription Factor 4
145891-90-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1271-1285Informations de copyright
© 2020 Federation of European Biochemical Societies.
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