Enhancer Function of MicroRNA-3681 Derived from Long Terminal Repeats Represses the Activity of Variable Number Tandem Repeats in the 3' UTR of
3' Untranslated Regions
Amino Acid Sequence
Animals
Binding Sites
Cell Line, Tumor
Computational Biology
Enhancer Elements, Genetic
Female
Gene Expression Regulation
/ genetics
Haplorhini
Humans
Male
Membrane Proteins
/ genetics
Mice
MicroRNAs
/ genetics
Minisatellite Repeats
Nerve Tissue Proteins
/ genetics
Pan troglodytes
RNA Recognition Motif Proteins
/ genetics
Real-Time Polymerase Chain Reaction
Terminal Repeat Sequences
/ genetics
HISA7
long terminal repeat
miR-3681-5p
transposable elements
variable number tandem repeat
Journal
Molecules and cells
ISSN: 0219-1032
Titre abrégé: Mol Cells
Pays: Korea (South)
ID NLM: 9610936
Informations de publication
Date de publication:
31 Jul 2020
31 Jul 2020
Historique:
received:
04
03
2020
revised:
12
05
2020
accepted:
27
05
2020
pubmed:
14
7
2020
medline:
4
6
2021
entrez:
14
7
2020
Statut:
ppublish
Résumé
microRNAs (miRNAs) are non-coding RNA molecules involved in the regulation of gene expression. miRNAs inhibit gene expression by binding to the 3' untranslated region (UTR) of their target gene. miRNAs can originate from transposable elements (TEs), which comprise approximately half of the eukaryotic genome and one type of TE, called the long terminal repeat (LTR) is found in class of retrotransposons. Amongst the miRNAs derived from LTR, hsa-miR-3681 was chosen and analyzed using bioinformatics tools and experimental analysis. Studies on hsa-miR-3681 have been scarce and this study provides the relative expression analysis of hsa-miR-3681-5p from humans, chimpanzees, crab-eating monkeys, and mice. Luciferase assay for hsa-miR-3681-5p and its target gene
Identifiants
pubmed: 32655015
pii: molcells.2020.0058
doi: 10.14348/molcells.2020.0058
pmc: PMC7398795
doi:
Substances chimiques
3' Untranslated Regions
0
Membrane Proteins
0
MicroRNAs
0
Nerve Tissue Proteins
0
RNA Recognition Motif Proteins
0
Shisa7 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
607-618Références
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