Voriconazole topical cream formulation: evidence for stability and antifungal activity.

Administration, Topical Adult Antifungal Agents / therapeutic use Arm / microbiology Drug Interactions Fusariosis / drug therapy Fusarium / drug effects Humans Male Skin Cream / administration & dosage Voriconazole / therapeutic use
Fusarium solani Voriconazole fungi skin infection stability topical

Journal

International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 09 04 2020
revised: 22 06 2020
accepted: 05 07 2020
pubmed: 14 7 2020
medline: 20 5 2021
entrez: 14 7 2020
Statut: ppublish

Résumé

Systemic use of voriconazole (VCZ) might be restricted by adverse events, such as hepatotoxicity and neurotoxicity, or drug-drug interactions. Topical VCZ application to skin may help to treat local infection more effectively and limit unwanted whole-body exposure. Topical VCZ cream was stable for 90 days when refrigerated. A patient with cutaneous Fusarium solani infection on his right forearm was successfully treated with topical 1% VCZ cream after failure of oral VCZ treatment.

Identifiants

DOI: 10.1016/j.ijantimicag.2020.106083 PMID: 32659465
pubmed: 32659465
pii: S0924-8579(20)30253-3
doi: 10.1016/j.ijantimicag.2020.106083
pii:
doi:

Substances chimiques

Antifungal Agents 0
Voriconazole JFU09I87TR

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106083

Informations de copyright

Copyright © 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Auteurs

Camille Bouchand (C)

Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France.

David Nguyen (D)

Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France.

Philippe-Henri Secretan (PH)

Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France.

Fabrice Vidal (F)

Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France.

Romain Guery (R)

Paris Descartes University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants Malades Hospital, AP-HP, IHU Imagine, Paris, France.

Sylvain Auvity (S)

Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France; Inserm UMR-S 1144, Université Paris Descartes, Paris, France.

Jeremie F Cohen (JF)

Paris Descartes University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants Malades Hospital, AP-HP, IHU Imagine, Paris, France.

Fanny Lanternier (F)

Paris Descartes University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants Malades Hospital, AP-HP, IHU Imagine, Paris, France; Institut Pasteur, National Reference Center for Invasive Mycoses and Antifungals, Molecular Mycology Unit, CNRS UMR2000, Paris, France.

Olivier Lortholary (O)

Paris Descartes University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants Malades Hospital, AP-HP, IHU Imagine, Paris, France; Institut Pasteur, National Reference Center for Invasive Mycoses and Antifungals, Molecular Mycology Unit, CNRS UMR2000, Paris, France.

Salvatore Cisternino (S)

Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France; Inserm UMR-S 1144, Université Paris Descartes, Paris, France.

Joël Schlatter (J)

Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France. Electronic address: joel.schlatter@aphp.fr.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie topique › Voriconazole topical cream formulation:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Voriconazole topical cream formulation:...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › Voriconazole topical cream formulation:...
questionsmedicales.fr › Régions du corps › Membres › Membre supérieur › Bras › Voriconazole topical cream formulation:...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Voriconazole topical cream formulation:...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Infections de la peau › Mycoses cutanées › Hyalohyphomycose › Fusariose › Voriconazole topical cream formulation:...
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Fusarium › Voriconazole topical cream formulation:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Voriconazole topical cream formulation:...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits domestiques › Cosmétiques › Crème pour la peau › Voriconazole topical cream formulation:...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Voriconazole › Voriconazole topical cream formulation:...