Crystallographic snapshots of UDP-glucuronic acid 4-epimerase ligand binding, rotation, and reduction.

Bacillus cereus / enzymology Bacterial Proteins / chemistry Carbohydrate Epimerases / chemistry Crystallography, X-Ray Ligands NAD / chemistry Oxidation-Reduction Rotation Uridine Diphosphate Sugars / chemistry
NADH SDR UDP-galacturonic acid UDP-glucuronic acid catalytic intermediates crystal structure decarboxylase dehydrogenase enzyme mechanism epimerase kinetic isotope effect nicotinamide adenine dinucleotide (NAD) short-chain dehydrogenase/reductase substrate specificity

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
28 08 2020
Historique:
received: 08 06 2020
revised: 10 07 2020
pubmed: 15 7 2020
medline: 20 1 2021
entrez: 15 7 2020
Statut: ppublish

Résumé

UDP-glucuronic acid is converted to UDP-galacturonic acid en route to a variety of sugar-containing metabolites. This reaction is performed by a NAD

Identifiants

DOI: 10.1074/jbc.RA120.014692 PMID: 32661196 PMC: PMC7458814
pubmed: 32661196
pii: S0021-9258(17)49486-5
doi: 10.1074/jbc.RA120.014692
pmc: PMC7458814
doi:

Substances chimiques

Bacterial Proteins 0
Ligands 0
Uridine Diphosphate Sugars 0
NAD 0U46U6E8UK
Carbohydrate Epimerases EC 5.1.3.-

Banques de données

PDB
['1UDA', '6KV9', '6ZLA', '6ZL6', '6ZLD', '6ZLK', '6ZLJ', '6ZLL', '6H0N', '5U4Q']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12461-12473

Informations de copyright

© 2020 Iacovino et al.

Déclaration de conflit d'intérêts

Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.

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Auteurs

Luca Giacinto Iacovino (LG)

Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.

Simone Savino (S)

Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria.
ORCID: 0000-0001-9505-3348

Annika J E Borg (AJE)

Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria.
ORCID: 0000-0003-1311-6910

Claudia Binda (C)

Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.
ORCID: 0000-0003-2038-9845

Bernd Nidetzky (B)

Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria bernd.nidetzky@tugraz.at andrea.mattevi@unipv.it.
Austrian Centre of Industrial Biotechnology, Graz, Austria.
ORCID: 0000-0002-5030-2643

Andrea Mattevi (A)

Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy bernd.nidetzky@tugraz.at andrea.mattevi@unipv.it.
ORCID: 0000-0002-9523-7128

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Bacillaceae › Bacillus › Bacillus cereus › Crystallographic snapshots of UDP-glucuronic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Crystallographic snapshots of UDP-glucuronic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Racémases et épimérases › Carbohydrate epimerases › Crystallographic snapshots of UDP-glucuronic...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Crystallographic snapshots of UDP-glucuronic...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Crystallographic snapshots of UDP-glucuronic...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › Crystallographic snapshots of UDP-glucuronic...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Crystallographic snapshots of UDP-glucuronic...
questionsmedicales.fr › Phénomènes physiques › Déplacement › Rotation › Crystallographic snapshots of UDP-glucuronic...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides uridyliques › Uridine diphosphate › Uridine diphosphate ose › Crystallographic snapshots of UDP-glucuronic...