Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?
Angiotensin-Converting Enzyme 2
Betacoronavirus
/ metabolism
COVID-19
Coronavirus Infections
/ metabolism
Female
Humans
Pandemics
Peptidyl-Dipeptidase A
/ genetics
Placenta
/ metabolism
Pneumonia, Viral
/ metabolism
Pregnancy
Receptors, Virus
/ genetics
SARS-CoV-2
Serine Endopeptidases
/ genetics
Virus Internalization
Zika Virus
Zika Virus Infection
COVID-19
SARS-CoV-2
genetics
genomics
human
human biology
medicine
placenta
pregnancy vertical transmisssion
scRNA-seq
viral receptors
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
14 07 2020
14 07 2020
Historique:
received:
13
05
2020
accepted:
06
07
2020
pubmed:
15
7
2020
medline:
1
8
2020
entrez:
15
7
2020
Statut:
epublish
Résumé
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 10 million people, including pregnant women. To date, no consistent evidence for the vertical transmission of SARS-CoV-2 exists. The novel coronavirus canonically utilizes the angiotensin-converting enzyme 2 (ACE2) receptor and the serine protease TMPRSS2 for cell entry. Herein, building upon our previous single-cell study (Pique-Regi et al., 2019), another study, and new single-cell/nuclei RNA-sequencing data, we investigated the expression of ACE2 and TMPRSS2 throughout pregnancy in the placenta as well as in third-trimester chorioamniotic membranes. We report that co-transcription of ACE2 and TMPRSS2 is negligible in the placenta, thus not a likely path of vertical transmission for SARS-CoV-2. By contrast, receptors for Zika virus and cytomegalovirus, which cause congenital infections, are highly expressed by placental cell types. These data show that the placenta minimally expresses the canonical cell-entry mediators for SARS-CoV-2.
Identifiants
pubmed: 32662421
doi: 10.7554/eLife.58716
pii: 58716
pmc: PMC7367681
doi:
pii:
Substances chimiques
Receptors, Virus
0
Peptidyl-Dipeptidase A
EC 3.4.15.1
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Serine Endopeptidases
EC 3.4.21.-
TMPRSS2 protein, human
EC 3.4.21.-
Banques de données
dbGaP
['phs001886.v2.p1']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wayne State University
ID : Perinatal Research Initiative
Pays : International
Organisme : NIH HHS
ID : HHSN275201300006C
Pays : United States
Déclaration de conflit d'intérêts
RP, RR, AT, FL, YX, AA, YL, CH, NG No competing interests declared
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