A two-lane mechanism for selective biological ammonium transport.
E. coli
SSME
Saccharomyces cerevisiae
ammonium transporter
biochemistry
chemical biology
nitrosomonas europaea
rhesus protein
transport selectivity
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
14 07 2020
14 07 2020
Historique:
received:
24
03
2020
accepted:
13
07
2020
pubmed:
15
7
2020
medline:
24
2
2021
entrez:
15
7
2020
Statut:
epublish
Résumé
The transport of charged molecules across biological membranes faces the dual problem of accommodating charges in a highly hydrophobic environment while maintaining selective substrate translocation. This has been the subject of a particular controversy for the exchange of ammonium across cellular membranes, an essential process in all domains of life. Ammonium transport is mediated by the ubiquitous Amt/Mep/Rh transporters that includes the human Rhesus factors. Here, using a combination of electrophysiology, yeast functional complementation and extended molecular dynamics simulations, we reveal a unique two-lane pathway for electrogenic NH
Identifiants
pubmed: 32662768
doi: 10.7554/eLife.57183
pii: 57183
pmc: PMC7447429
doi:
pii:
Substances chimiques
Ammonium Compounds
0
Ammonia
7664-41-7
Banques de données
figshare
['10.6084/m9.figshare.12826316']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Tenovus
ID : S17-07
Pays : International
Organisme : Natural Environment Research Council
ID : NE/M001415/1
Pays : International
Organisme : Fonds De La Recherche Scientifique - FNRS
ID : WELBIO grant ref: CR-2019A-05R.
Pays : International
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Informations de copyright
© 2020, Williamson et al.
Déclaration de conflit d'intérêts
GW, GT, AB, MB, GD, MB, AP, CI, ET, PH, AM, UZ, AJ No competing interests declared
Références
Annu Rev Biophys. 2014;43:211-32
pubmed: 24773017
J Biol Chem. 2013 May 17;288(20):14080-14086
pubmed: 23546877
Front Plant Sci. 2016 Mar 31;7:352
pubmed: 27066024
Nature. 2008 Nov 20;456(7220):339-43
pubmed: 19020613
Curr Protoc Mol Biol. 2002 Aug;Chapter 1:Unit 1.1
pubmed: 18265292
Mol Microbiol. 2000 Jul;37(2):331-44
pubmed: 10931328
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19303-8
pubmed: 18032606
Nucleic Acids Res. 2016 Jul 8;44(W1):W344-50
pubmed: 27166375
J Biol Chem. 2020 Mar 6;295(10):3362-3370
pubmed: 31988244
Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9995-10000
pubmed: 24958855
FEMS Microbiol Lett. 2007 Aug;273(2):260-7
pubmed: 17608700
J Mol Graph. 1996 Dec;14(6):354-60, 376
pubmed: 9195488
Science. 2004 Sep 10;305(5690):1587-94
pubmed: 15361618
J Bacteriol. 2007 Dec;189(24):9090-100
pubmed: 17921289
Nat Chem. 2018 Aug;10(8):813-820
pubmed: 30030538
Proteins. 2006 Sep 1;64(4):829-44
pubmed: 16779836
J Mol Biol. 1980 Jun 5;139(4):691-704
pubmed: 6251229
Sci Adv. 2018 Sep 12;4(9):eaar3599
pubmed: 30214933
J Chem Theory Comput. 2016 Jan 12;12(1):405-13
pubmed: 26631602
J Phys Chem Lett. 2018 Jul 19;9(14):3910-3914
pubmed: 29939747
J Mol Biol. 1996 Jul 19;260(3):289-98
pubmed: 8757792
Proteins. 2000 Jun 1;39(4):393-407
pubmed: 10813821
Biochemistry. 1980 Jul 22;19(15):3585-90
pubmed: 6996707
Biochim Biophys Acta. 2016 Jul;1858(7 Pt B):1741-52
pubmed: 26874204
Nucleic Acids Res. 1992 Mar 25;20(6):1425
pubmed: 1561104
Nucleic Acids Res. 1994 Dec 25;22(25):5767-8
pubmed: 7838736
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19279-84
pubmed: 18040042
J Biol Chem. 2006 Dec 22;281(51):39492-8
pubmed: 17040913
Biochem J. 2006 Jun 15;396(3):431-7
pubmed: 16499477
Curr Genet. 2006 Jun;49(6):364-74
pubmed: 16477434
J Am Chem Soc. 2012 Jun 27;134(25):10419-27
pubmed: 22631217
EMBO J. 2017 Apr 3;36(7):949-958
pubmed: 28250043
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9638-43
pubmed: 20457942
Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15075-80
pubmed: 20689043
Biophys J. 2006 Dec 15;91(12):4401-12
pubmed: 17012311
NPJ Syst Biol Appl. 2019 Apr 12;5:14
pubmed: 30993002
Channels (Austin). 2014;8(6):496-502
pubmed: 25483282
J Am Chem Soc. 2007 Feb 7;129(5):1210-5
pubmed: 17263403
Biophys J. 2007 May 1;92(9):L82-4
pubmed: 17351012
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17090-5
pubmed: 15563598
J Exp Bot. 2010 May;61(9):2303-15
pubmed: 20339151
Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):14994-9
pubmed: 16214888
J Am Chem Soc. 2010 Sep 29;132(38):13251-63
pubmed: 20815391
Mol Cell Biol. 1997 Aug;17(8):4282-93
pubmed: 9234685
J Biol Chem. 2002 Apr 19;277(16):13548-55
pubmed: 11821433
FASEB J. 2019 Feb;33(2):1989-1999
pubmed: 30211659
J Biol Chem. 2004 Mar 5;279(10):8530-8
pubmed: 14668330
Phys Chem Chem Phys. 2020 Jan 28;22(4):2540-2548
pubmed: 31942893
Methods Enzymol. 2017;594:31-83
pubmed: 28779843
J Chem Theory Comput. 2012 Sep 11;8(9):3257-3273
pubmed: 23341755
J Chem Phys. 2007 Jan 7;126(1):014101
pubmed: 17212484
FEBS Lett. 2011 Jan 3;585(1):23-8
pubmed: 21134373
Blood. 2009 Feb 5;113(6):1350-7
pubmed: 18931342
FEBS Lett. 1995 Aug 21;370(3):264-8
pubmed: 7656990
Cell Mol Life Sci. 2010 Apr;67(8):1203-18
pubmed: 19953292
Nat Commun. 2016 Apr 18;7:11337
pubmed: 27088325