Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT
Anilides
/ chemical synthesis
Animals
CHO Cells
Central Nervous System Agents
/ chemical synthesis
Cricetulus
Cyclic Nucleotide Phosphodiesterases, Type 4
/ metabolism
Cyclic Nucleotide Phosphodiesterases, Type 7
/ antagonists & inhibitors
HEK293 Cells
Humans
Male
Microsomes, Liver
/ metabolism
Molecular Docking Simulation
Molecular Structure
Open Field Test
/ drug effects
Phosphodiesterase 4 Inhibitors
/ chemical synthesis
Piperazines
/ chemical synthesis
Protein Binding
Rats, Wistar
Receptor, Serotonin, 5-HT1A
/ metabolism
Receptors, Serotonin
/ metabolism
Serotonin 5-HT1 Receptor Antagonists
/ chemical synthesis
Sf9 Cells
Structure-Activity Relationship
1-(2-methoxyphenyl)piperazine derivative
5-HT(1A)/5-HT(7) receptor antagonist
Anilide
Benzylamide
PDE4/PDE7 inhibitor
Procognitive and antidepressant activity
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
03
03
2020
revised:
05
05
2020
accepted:
06
05
2020
pubmed:
17
7
2020
medline:
7
4
2021
entrez:
17
7
2020
Statut:
ppublish
Résumé
A library of novel anilide and benzylamide derivatives of ω-(4-(2-methoxyphenyl)piperazin-1-yl)alkanoic acids as combined 5-HT
Identifiants
pubmed: 32673902
pii: S0223-5234(20)30408-6
doi: 10.1016/j.ejmech.2020.112437
pii:
doi:
Substances chimiques
Anilides
0
Central Nervous System Agents
0
Phosphodiesterase 4 Inhibitors
0
Piperazines
0
Receptors, Serotonin
0
Serotonin 5-HT1 Receptor Antagonists
0
serotonin 7 receptor
0
Receptor, Serotonin, 5-HT1A
112692-38-3
Cyclic Nucleotide Phosphodiesterases, Type 4
EC 3.1.4.17
Cyclic Nucleotide Phosphodiesterases, Type 7
EC 3.1.4.17
PDE4B protein, human
EC 3.1.4.17
PDE7A protein, human
EC 3.1.4.17
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112437Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.