The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge.
colon
constipation
magnetic resonance imaging
reproducibility
Journal
Neurogastroenterology and motility
ISSN: 1365-2982
Titre abrégé: Neurogastroenterol Motil
Pays: England
ID NLM: 9432572
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
15
01
2020
revised:
01
06
2020
accepted:
18
06
2020
pubmed:
18
7
2020
medline:
16
9
2021
entrez:
18
7
2020
Statut:
ppublish
Résumé
Magnetic resonance imaging (MRI) of the colonic response to a macrogol challenge drink can be used to assess the mechanisms underlying severe constipation. We measured the intrasubject reproducibility of MRI measures of colonic function to aid their implementation as a possible clinical test. Healthy participants attended for MRI on two occasions (identical protocols, minimum 1 week apart). They underwent a fasted scan and then consumed the macrogol drink. Subjects were scanned at 60 and 120 minutes, with maximum value reached used for comparison. The colonic volume, water content, mixing of colonic content and the movement of the colon walls were measured. Coefficients of variation and intraclass correlation coefficients (ICC) were calculated. Twelve participants completed the study: nine female, mean age 26 years (SD 5) and body mass index 24.8 kg/m The colonic response to the macrogol stimulus as assessed by MRI is heterogeneous but large compared to baseline, with moderate to good reproducibility, making the test suitable to study potential pathologies underlying GI disorders such as constipation. More data are needed to better define the normal range for comparison with patient groups who may have both hypo- and hypermotile responses.
Sections du résumé
BACKGROUND
Magnetic resonance imaging (MRI) of the colonic response to a macrogol challenge drink can be used to assess the mechanisms underlying severe constipation. We measured the intrasubject reproducibility of MRI measures of colonic function to aid their implementation as a possible clinical test.
METHODS
Healthy participants attended for MRI on two occasions (identical protocols, minimum 1 week apart). They underwent a fasted scan and then consumed the macrogol drink. Subjects were scanned at 60 and 120 minutes, with maximum value reached used for comparison. The colonic volume, water content, mixing of colonic content and the movement of the colon walls were measured. Coefficients of variation and intraclass correlation coefficients (ICC) were calculated.
RESULTS
Twelve participants completed the study: nine female, mean age 26 years (SD 5) and body mass index 24.8 kg/m
CONCLUSIONS
The colonic response to the macrogol stimulus as assessed by MRI is heterogeneous but large compared to baseline, with moderate to good reproducibility, making the test suitable to study potential pathologies underlying GI disorders such as constipation. More data are needed to better define the normal range for comparison with patient groups who may have both hypo- and hypermotile responses.
Substances chimiques
Surface-Active Agents
0
Water
059QF0KO0R
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13942Subventions
Organisme : Medical Research Council
ID : MR/N026810/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd.
Références
Suares NC, Ford AC. Prevalence of and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol. 2011;106(9):1582-1591.
Belsey J, Greenfield S, Candy D, Geraint M. Systematic review: impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther. 2010;31(9):938-949.
Emmanuel A, Spinks J. The Cost of Constipation Report. 2016. internal-pdf://111.117.158.86/Cost_of_Constipation_Report_FINAL.pdf
Johanson JF, Kralstein J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther. 2007;25(5):599-608.
Lam C, Chaddock G, Marciani L, et al. Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation. Neurogastroenterol Motil. 2016;28(6):861-870.
Marciani L, Garsed KC, Hoad CL, et al. Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI: comparison of split vs single dose. Neurogastroenterol Motil. 2014;26(10):1426-1436.
Degen LP, Phillips SF. Variability of gastrointestinal transit in healthy women and men. Gut. 1996;39(2):299-305.
Brophy CM, Moore JG, Christian PE, et al. Variability of gastric emptying measurements in man employing standardized radiolabeled meals. Dig Dis Sci. 1986;31(8):799-806.
Rao SSC, Singh S, Mudipalli R. Day-to-day reproducibility of prolonged ambulatory colonic manometry in healthy subjects. Neurogastroenterol Motil. 2010;22(6):640-e178.
Odunsi ST, Camilleri M, Bharucha AE, et al. Reproducibility and performance characteristics of colonic compliance, tone, and sensory tests in healthy humans. Dig Dis Sci. 2010;55(3):709-715.
Cremonini F, Mullan BP, Camilleri M, Burton DD, Rank MR. Performance characteristics of scintigraphic transit measurements for studies of experimental therapies. Aliment Pharmacol Ther. 2002;16:1781-1790.
Talley NJ, Phillips SF, Melton LJ, Wiltgen C, Zinsmeister AR. A patient questionnaire to identify bowel disease. Ann Intern Med. 1989;111(8):671.
Tornblom H, Van Oudenhove L, Sadik R, et al. Colonic transit time and IBS symptoms: what’s the link? Am J Gastroenterol. 2012;107(5):754-760.
Eggers H, Brendel B, Duijndam A, Herigault G. Dual-echo Dixon imaging with flexible choice of echo times. Magn Reson Med. 2011;65(1):96-107.
Pritchard SE, Marciani L, Garsed KC, et al. Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea-predominant irritable bowel syndrome measured using serial MRI. Neurogastroenterol Motil. 2014;26(1):124-130.
Hoad CL, Marciani L, Foley S, et al. Non-invasive quantification of small bowel water content by MRI: a validation study. Phys Med Biol. 2007;52(23):6909-6922.
Pritchard SE, Paul J, Major G, et al. Assessment of motion of colonic contents in the human colon using MRI tagging. Neurogastroenterol Motil. 2017;29(9):e13091.
Menys A, Hamy V, Makanyanga J, et al. Dual registration of abdominal motion for motility assessment in free-breathing data sets acquired using dynamic MRI. Phys Med Biol. 2014;59(16):4603-4619.
Hoad CL, Menys A, Garsed K, et al. Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI. Neurogastroenterol Motil. 2016;28(3):327-335.
Menys A, Hoad C, Spiller R, et al. Spatio-temporal motility MRI analysis of the stomach and colon. Neurogastroenterol Motil. 2019;31:e13557.
Bland JM, Altman DG. Measuring agreement in method comparison studies. Stat Methods Med Res. 1999;8(2):135-160.
Koo TK, Li MY. A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med. 2016;15(2):155-163.
Julious SA. Sample size of 12 per group rule of thumb for a pilot study. Pharm Stat. 2005;4(4):287-291.
Major G, Pritchard S, Murray K, et al. Colon hypersensitivity to distension, rather than excessive gas production, produces carbohydrate-related symptoms in individuals with irritable bowel syndrome. Gastroenterology. 2017;152(1):124-133.e2.
Nilsson M, Sandberg TH, Poulsen JL, et al. Quantification and variability in colonic volume with a novel magnetic resonance imaging method. Neurogastroenterol Motil. 2015;27(12):1755-1763.
Dinning PG, Wiklendt L, Maslen L, et al. Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry. Neurogastroenterol Motil. 2014;26(10):1443-1457.
Kirchhoff S, Nicolaus M, Schirra J, Reiser MF, Göke B, Lienemann A. Assessment of colon motility using simultaneous manometric and functional cine-MRI analysis: preliminary results. Abdom Imaging. 2011;36(1):24-30.