Projections from the dorsomedial division of the bed nucleus of the stria terminalis to hypothalamic nuclei in the mouse.
Agouti-Related Protein
/ analysis
Amygdala
/ anatomy & histology
Animals
Axonal Transport
Feeding Behavior
/ physiology
Hypothalamic Hormones
/ analysis
Hypothalamus
/ anatomy & histology
Luminescent Proteins
/ analysis
Male
Melanins
/ analysis
Mice
/ anatomy & histology
Mice, Inbred C57BL
Nerve Tissue Proteins
/ analysis
Neural Pathways
/ anatomy & histology
Neurons
/ chemistry
Orexins
/ analysis
Phytohemagglutinins
/ analysis
Pituitary Hormones
/ analysis
Proprotein Convertases
/ analysis
Rabies virus
Septal Nuclei
/ anatomy & histology
Species Specificity
Tyrosine 3-Monooxygenase
/ analysis
Red Fluorescent Protein
AgRP/NPY
MCH
ORX
POMC
anterograde and retrograde tract tracing
dorsomedial division of the bed nucleus of the stria terminalis
hypothalamic nuclei
Journal
The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
14
05
2020
revised:
30
06
2020
accepted:
14
07
2020
pubmed:
18
7
2020
medline:
19
1
2022
entrez:
18
7
2020
Statut:
ppublish
Résumé
As stressful environment is a potent modulator of feeding, we seek in the present work to decipher the neuroanatomical basis for an interplay between stress and feeding behaviors. For this, we combined anterograde and retrograde tracing with immunohistochemical approaches to investigate the patterns of projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH) and dorsomedial (DMH), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and motivated behaviors. We particularly focused our study on afferences to proopiomelanocortin (POMC), agouti-related peptide (AgRP), melanin-concentrating-hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respectively. We found light to intense innervation of all these hypothalamic nuclei. We particularly showed an innervation of POMC, AgRP, MCH and ORX neurons by the dorsomedial and dorsolateral divisions of the BNST. Therefore, these results lay the foundation for a better understanding of the neuroanatomical basis of the stress-related feeding behaviors.
Identifiants
pubmed: 32678476
doi: 10.1002/cne.24988
pmc: PMC7891577
doi:
Substances chimiques
Agouti-Related Protein
0
Hypothalamic Hormones
0
Luminescent Proteins
0
Melanins
0
Nerve Tissue Proteins
0
Orexins
0
Phytohemagglutinins
0
Pituitary Hormones
0
leukoagglutinins, plants
0
melanin-concentrating hormone
67382-96-1
Tyrosine 3-Monooxygenase
EC 1.14.16.2
Proprotein Convertases
EC 3.4.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
929-956Informations de copyright
© 2020 The Authors. The Journal of Comparative Neurology published by Wiley Periodicals LLC.
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