An agent-based simulator for the gastrointestinal pathway of Listeria monocytogenes.
Food matrix
Foodborne pathogen
Individual-based model
Pathogen survival
Stomach emptying time
Stomach pH dynamics
Journal
International journal of food microbiology
ISSN: 1879-3460
Titre abrégé: Int J Food Microbiol
Pays: Netherlands
ID NLM: 8412849
Informations de publication
Date de publication:
16 Nov 2020
16 Nov 2020
Historique:
received:
28
07
2019
revised:
29
11
2019
accepted:
28
06
2020
pubmed:
22
7
2020
medline:
3
11
2020
entrez:
22
7
2020
Statut:
ppublish
Résumé
We developed an agent-based gastric simulator for a human host to illustrate the within host survival mechanisms of Listeria monocytogenes. The simulator incorporates the gastric physiology and digestion processes that are critical for pathogen survival in the stomach. Mathematical formulations for the pH dynamics, stomach emptying time, and survival probability in the presence of gastric acid are integrated in the simulator to evaluate the portion of ingested bacteria that survives in the stomach and reaches the small intestine. The parameters are estimated using in vitro data relevant to the human stomach and L. monocytogenes. The simulator predicts that 5%-29% of ingested bacteria can survive a human stomach and reach the small intestine. In the absence of extensive scientific experiments, which are not feasible on the grounds of ethical and safety concerns, this simulator may provide a supplementary tool to evaluate pathogen survival and subsequent infection, especially with regards to the ingestion of small doses.
Identifiants
pubmed: 32693315
pii: S0168-1605(20)30270-1
doi: 10.1016/j.ijfoodmicro.2020.108776
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108776Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.