Triplex-Forming Peptide Nucleic Acids with Extended Backbones.
isothermal titration calorimetry
modified backbones
peptide nucleic acids
triple helixes
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
received:
02
07
2020
revised:
20
07
2020
pubmed:
23
7
2020
medline:
8
7
2021
entrez:
23
7
2020
Statut:
ppublish
Résumé
Peptide nucleic acid (PNA) forms a triple helix with double-stranded RNA (dsRNA) stabilized by a hydrogen-bonding zipper formed by PNA's backbone amides (N-H) interacting with RNA phosphate oxygens. This hydrogen-bonding pattern is enabled by the matching ∼5.7 Å spacing (typical for A-form dsRNA) between PNA's backbone amides and RNA phosphate oxygens. We hypothesized that extending the PNA's backbone by one -CH
Identifiants
pubmed: 32697857
doi: 10.1002/cbic.202000432
pmc: PMC7783598
mid: NIHMS1654394
doi:
Substances chimiques
Peptide Nucleic Acids
0
RNA
63231-63-0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3410-3416Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM130207
Pays : United States
Informations de copyright
© 2020 Wiley-VCH GmbH.
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