A Microdose Cocktail to Evaluate Drug Interactions in Patients with Renal Impairment.
ATP Binding Cassette Transporter, Subfamily B, Member 1
/ metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2
/ metabolism
Area Under Curve
Biomarkers
/ metabolism
Drug Interactions
/ physiology
Healthy Volunteers
Humans
Kidney Diseases
/ metabolism
Liver-Specific Organic Anion Transporter 1
/ metabolism
Midazolam
/ pharmacokinetics
Rifampin
/ pharmacokinetics
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
13
05
2020
accepted:
08
07
2020
pubmed:
25
7
2020
medline:
22
5
2021
entrez:
25
7
2020
Statut:
ppublish
Résumé
Renal impairment (RI) is known to influence the pharmacokinetics of nonrenally eliminated drugs, although the mechanism and clinical impact is poorly understood. We assessed the impact of RI and single dose oral rifampin (RIF) on the pharmacokinetics of CYP3A, OATP1B, P-gp, and BCRP substrates using a microdose cocktail and OATP1B endogenous biomarkers. RI alone had no impact on midazolam (MDZ), maximum plasma concentration (C
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B, Member 1
0
ATP Binding Cassette Transporter, Subfamily G, Member 2
0
Biomarkers
0
Liver-Specific Organic Anion Transporter 1
0
Midazolam
R60L0SM5BC
Rifampin
VJT6J7R4TR
Types de publication
Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
403-415Informations de copyright
© 2020 Merck Sharp & Dohme Corp. Clinical Pharmacology & Therapeutics © 2020 American Society for Clinical Pharmacology and Therapeutics.
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