Effects of dose and type of corticosteroids on the divergence between estimated glomerular filtration rates derived from cystatin C and creatinine.
Adult
Aged
Aged, 80 and over
Creatinine
/ metabolism
Cystatin C
/ metabolism
Dose-Response Relationship, Drug
Female
Glomerular Filtration Rate
/ physiology
Glucocorticoids
/ administration & dosage
Humans
Kidney Function Tests
Male
Middle Aged
Prednisolone
/ administration & dosage
Retrospective Studies
Sensitivity and Specificity
Young Adult
corticosteroid
creatinine
cystatin C
dose-dependent
estimated glomerular filtration rate
Journal
Journal of clinical pharmacy and therapeutics
ISSN: 1365-2710
Titre abrégé: J Clin Pharm Ther
Pays: England
ID NLM: 8704308
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
08
03
2020
revised:
31
05
2020
accepted:
26
06
2020
pubmed:
25
7
2020
medline:
2
9
2021
entrez:
25
7
2020
Statut:
ppublish
Résumé
Cystatin C (Cys-C) is a useful diagnostic marker for early renal dysfunction, but has the disadvantage of giving false-positive results when corticosteroids are administered. In this study, we aimed to evaluate the dose-dependent effect of corticosteroids on the divergence between estimated glomerular filtration rates based on Cys-C (eGFRcys) and creatinine (eGFRcreat) and calculate the cut-off value of corticosteroid dose having an impact on eGFRcys/eGFRcreat ratio. This retrospective study included 305 patients (1318 therapies) treated with oral or injectable corticosteroids between June 2014 and May 2018, who did not meet the exclusion criteria. All corticosteroid doses were converted to prednisolone equivalent. Steroid dose correlated significantly with eGFRcys/eGFRcreat ratio for all corticosteroids and for prednisolone (r These findings suggest that results should be interpreted with caution when using eGFRcys as renal function marker in patients treated with prednisolone at doses of 0.170 mg/kg/day and higher.
Substances chimiques
CST3 protein, human
0
Cystatin C
0
Glucocorticoids
0
Prednisolone
9PHQ9Y1OLM
Creatinine
AYI8EX34EU
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1390-1397Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
Levey AS, Inker LA. Assessment of glomerular filtration rate in health and disease: a state of the art review. Clin Pharmacol Ther. 2017;102:405-419.
Levey AS, Greene T, Kusek JW, et al. A simplified equation to predict glomerular filtration rate from serum creatinine. J Am Soc Nephrol. 2000;11:A0828.
Matsuo S, Imai E, Horio M, et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53:982-992.
Heymsfield SB, Arteaga C, McManus C, et al. Measurement of muscle mass in humans: validity of the 24-hour urinary creatinine method. Am J Clin Nutr. 1983;37:478-494.
Stevens LA, Schmid CH, Greene T, et al. Factors other than glomerular filtration rate affect serum cystatin C levels. Kidney Int. 2009;75:652-660.
Goldberg TH, Finkelstein MS. Difficulties in estimating glomerular filtration rate in the elderly. Arch Intern Med. 1987;147:1430-1433.
Coll E, Botey A, Alvarez L, et al. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis. 2000;36:29-34.
Filler G, Bokenkamp A, Hofmann W, et al. Cystatin C as a marker of GFR-history, indications, and future research. Clin Biochem. 2005;38:1-8.
Pucci L, Triscornia S, Lucchesi D, et al. Cystatin C and estimates of renal function: searching for a better measure of kidney function in diabetic patients. Clin Chem. 2007;53:480-488.
Schaeffner ES, Ebert N, Delanaye P, et al. Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med. 2012;157:471-481.
Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis. 2002;40:221-226.
Horio M, Imai E, Yasuda Y, et al. GFR estimation using standardized serum cystatin C in Japan. Am J Kidney Dis. 2013;61:197-203.
Cimerman N, Brguljan PM, Krasovec M, et al. Serum cystatin C, a potent inhibitor of cysteine proteinases, is elevated in asthmatic patients. Clin Chim Acta. 2000;300:83-95.
Pöge U, Gerhardt T, Stoffel-Wagner B, et al. Cystatin C-based calculation of glomerular filtration rate in kidney transplant recipients. Kidney Int. 2006;70:204-210.
Jayagopal V, Keevil BG, Atkin SL, et al. Paradoxical changes in cystatin C and serum creatinine in patients with hypo- and hyperthyroidism. Clin Chem. 2003;49:680-681.
Kazama JJ, Kutsuwada K, Ataka K, et al. Serum cystatin C reliably detects renal dysfunction in patients with various renal diseases. Nephron. 2002;91:13-20.
Horio M, Imai E, Yasuda Y, et al. Performance of serum cystatin C versus serum creatinine as a marker of glomerular filtration rate as measured by inulin renal clearance. Clin Exp Nephrol. 2011;15:868-876.
Akama H. Topics of glucocorticoids-centered on therapy for rheumatoid arthritis. Nihon Rinsho Meneki Gakkai Kaishi. 2011;34:464-475.
Horio M, Yasuda Y, Kaimori J, et al. Performance of the Japanese glomerular filtration rate equation based on standardized serum cystatin C in potential kidney donors. Transplant Proc. 2014;46:314-317.
Tsujita M, Goto N, Yamamoto T, et al. How to estimate kidney function in kidney transplant recipients with mild to moderate kidney impairment: comparison of estimated glomerular filtration (eGFR) values between creatinine-based GFR equations and cystatin C-based GFR equations for Japanese population. Clin Exp Nephrol. 2014;18:130-134.
Menconi M, Fareed M, O'Neal P, et al. Role of glucocorticoids in the molecular regulation of muscle wasting. Crit Care Med. 2007;35(9 Suppl):S602-S608.
Risch L, Herklotz R, Blumberg A, et al. Effects of glucocorticoid immunosuppression on serum cystatin C concentrations in renal transplant patients. Clin Chem. 2001;47:2055-2059.
Nozawa Y, Sato H, Wakamatsu A, et al. Utility of estimated glomerular filtration rate using cystatin C and its interpretation in patients with rheumatoid arthritis under glucocorticoid therapy. Clin Chim Acta. 2018;487:299-305.
Bökenkamp A, Domanetzki M, Zinck R, et al. Cystatin C serum concentrations underestimate glomerular filtration rate in renal transplant recipients. Clin Chem. 1999;45:1866-1868.
Odden MC, Scherzer R, Bacchetti P, et al. Arch Intern Med. 2007;167:2213-2219.
Kos J, Krasovec M, Cimerman N, et al. Cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in sera from patients with colorectal cancer: relation to prognosis. Clin Cancer Res. 2000;6:505-511.
Kos J, Stabuc B, Schweiger A, Cathepsins B. H, and L and their inhibitors stefin A and cystatin C in sera of melanoma patients. Clin Cancer Res. 1997;3:1815-1822.
Arlt W, Allolio B. Adrenal insufficiency. Lancet. 2003;361:1881-1893.
Zhu XR, Ge N, Wang Y, et al. Corticosteroids significantly increase cystatin C levels in the plasma by promoting cystatin C production in rats. Ren Fail. 2019;41:698-703.
Bjarnadóttir M, Grubb A, Olafsson I. Promoter-mediated, dexamethasone-induced increase in cystatin C production by HeLa cells. Scand J Clin Lab Invest. 1995;55:617-623.