Arabidopsis C-terminal binding protein ANGUSTIFOLIA modulates transcriptional co-regulation of MYB46 and WRKY33.
(hemi)biotrophic and necrotrophic pathogens
ANGUSTIFOLIA
Arabidopsis
CtBP
SA and JA/ET antagonism
transcriptional reprogramming
Journal
The New phytologist
ISSN: 1469-8137
Titre abrégé: New Phytol
Pays: England
ID NLM: 9882884
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
27
01
2020
accepted:
26
06
2020
pubmed:
25
7
2020
medline:
27
4
2021
entrez:
25
7
2020
Statut:
ppublish
Résumé
The apparent antagonism between salicylic acid (SA) and jasmonic acid (JA)/ethylene (ET) signalling resulting in trade-offs between defence against (hemi)biotrophic and necrotrophic pathogens has been widely described across multiple plant species. However, the underlying mechanism remains to be fully established. The molecular and cellular functions of ANGUSTIFOLIA (AN) were characterised, and its role in regulating the pathogenic response was studied in Arabidopsis. We demonstrated that AN, a plant homologue of mammalian C-TERMINAL BINDING PROTEIN (CtBP), antagonistically regulates plant resistance to the hemibiotrophic pathogen Pseudomonas syringae and the necrotrophic pathogen Botrytis cinerea. Consistent with phenotypic observations, transcription of genes involved in SA and JA/ET pathways was antagonistically regulated by AN. By interacting with another nuclear protein TYROSYL-DNA PHOSPHODIESTERASE1 (TDP1), AN imposes transcriptional repression on MYB46, encoding a transcriptional activator of PHENYLALANINE AMMONIA-LYASE (PAL) genes which are required for SA biosynthesis, while releasing TDP1-imposed transcriptional repression on WRKY33, a master regulator of the JA/ET signalling pathway. These findings demonstrate that transcriptional co-regulation of MYB46 and WRKY33 by AN mediates the coordination of SA and JA/ET pathways to optimise defences against (hemi)biotrophic and necrotrophic pathogens.
Identifiants
pubmed: 32706429
doi: 10.1111/nph.16826
pmc: PMC7692920
doi:
Substances chimiques
ANGUSTIFOLIA protein, Arabidopsis
0
Arabidopsis Proteins
0
Cyclopentanes
0
DNA-Binding Proteins
0
Myb46 protein, Arabidopsis
0
Oxylipins
0
Repressor Proteins
0
Transcription Factors
0
WRKY33 protein, Arabidopsis
0
Alcohol Oxidoreductases
EC 1.1.-
C-terminal binding protein
EC 1.1.1.-
Salicylic Acid
O414PZ4LPZ
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1627-1639Informations de copyright
2020 UT-Batelle. New Phytologist © 2020 New Phytologist Trust.
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