Long-term renal function after treatment for unilateral, nonsyndromic Wilms tumor. A report from the St. Jude Lifetime Cohort Study.
Adult
Biomarkers
/ analysis
Blood Pressure Monitoring, Ambulatory
Case-Control Studies
Child, Preschool
Creatinine
/ analysis
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Hypertension
/ epidemiology
Kidney Function Tests
Kidney Neoplasms
/ pathology
Male
Pilot Projects
Prevalence
Prognosis
Prospective Studies
Radiotherapy
/ adverse effects
Renal Insufficiency, Chronic
/ epidemiology
Retrospective Studies
Survival Rate
Survivors
/ statistics & numerical data
United States
/ epidemiology
Wilms Tumor
/ pathology
Wilms tumor
hypertension
nephrectomy
renal function
whole abdomen radiation therapy
Journal
Pediatric blood & cancer
ISSN: 1545-5017
Titre abrégé: Pediatr Blood Cancer
Pays: United States
ID NLM: 101186624
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
16
10
2019
revised:
02
03
2020
accepted:
03
03
2020
pubmed:
25
7
2020
medline:
1
1
2021
entrez:
25
7
2020
Statut:
ppublish
Résumé
The impact of specific treatment modalities on long-term renal function and blood pressure among adult survivors of Wilms tumor (WT) has not been well documented. Among 40 WT survivors and 35 noncancer controls, we estimated the glomerular filtration rate (eGFR) using the Chronic Kidney Disease-Epidemiology (CKD-EPI) equations with and without cystatin C, obtained 24-hour ambulatory blood pressure readings, and, among survivors only, measured Twenty-six (65%) WT survivors were female, and 33 (83%) were non-Hispanic white. GFR estimated with creatinine or creatinine + cystatin C was decreased among irradiated survivors compared with controls. No irradiated or unirradiated participant had an eGFR (creatinine + cystatin C) < 60 mL/min/1.73 m Chronic kidney disease was infrequent in long-term survivors of unilateral nonsyndromic WT, whether treated with WART or no radiation. The prevalence of hypertension was increased in both groups compared with controls, emphasizing the need for ongoing monitoring of renal and cardiovascular health.
Sections du résumé
BACKGROUND
The impact of specific treatment modalities on long-term renal function and blood pressure among adult survivors of Wilms tumor (WT) has not been well documented.
METHODS
Among 40 WT survivors and 35 noncancer controls, we estimated the glomerular filtration rate (eGFR) using the Chronic Kidney Disease-Epidemiology (CKD-EPI) equations with and without cystatin C, obtained 24-hour ambulatory blood pressure readings, and, among survivors only, measured
RESULTS
Twenty-six (65%) WT survivors were female, and 33 (83%) were non-Hispanic white. GFR estimated with creatinine or creatinine + cystatin C was decreased among irradiated survivors compared with controls. No irradiated or unirradiated participant had an eGFR (creatinine + cystatin C) < 60 mL/min/1.73 m
CONCLUSIONS
Chronic kidney disease was infrequent in long-term survivors of unilateral nonsyndromic WT, whether treated with WART or no radiation. The prevalence of hypertension was increased in both groups compared with controls, emphasizing the need for ongoing monitoring of renal and cardiovascular health.
Identifiants
pubmed: 32706494
doi: 10.1002/pbc.28271
pmc: PMC7735383
mid: NIHMS1639993
doi:
Substances chimiques
Biomarkers
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e28271Subventions
Organisme : NCI NIH HHS
ID : CA21765
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA021765
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA195547
Pays : United States
Organisme : NCI NIH HHS
ID : CA195547
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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