RORC overexpression as a sign of Th17 lymphocytes accumulation in multiple myeloma bone marrow.
IL-17
IL-17R
Multiple myeloma
RORC
Th17
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
28
05
2020
revised:
06
07
2020
accepted:
13
07
2020
pubmed:
25
7
2020
medline:
17
11
2021
entrez:
25
7
2020
Statut:
ppublish
Résumé
The role of the bone marrow microenvironment in supporting the proliferation and survival of the abnormal plasma cells in multiple myeloma (MM) is well established. Such microenvironment is rich of cytokines like IL-6, TGF-β, IL-1 and IL-23 which are known to promote the differentiation of Th17 lymphocytes, a T helper subpopulation. Th17 cells secrete IL-17, a cytokine involved in the pathophysiology of several auto-immune diseases. Yet, its involvement in cancers remains unclear. Herein, we aimed to try to understand the role of Th17 lymphocytes in multiple myeloma. Bone marrow samples were prospectively collected from 29 MM patients and 23 healthy bone marrow donors for allograft. Mononuclear bone marrow cells were isolated by Ficoll-Hypaque gradient and CD138
Identifiants
pubmed: 32707421
pii: S1043-4666(20)30226-X
doi: 10.1016/j.cyto.2020.155210
pii:
doi:
Substances chimiques
Interleukin-17
0
Nuclear Receptor Subfamily 1, Group F, Member 3
0
RORC protein, human
0
Receptors, Interleukin-17
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
155210Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.