Therapeutic Potential of Polyphenols-Loaded Polymeric Nanoparticles in Cardiovascular System.
Animals
Antioxidants
/ chemistry
Atherosclerosis
/ drug therapy
Biological Availability
Biological Products
/ chemistry
Cardiovascular System
/ drug effects
Curcumin
/ chemistry
Drug Compounding
Heart Failure
/ drug therapy
Humans
Hypertension
/ drug therapy
Nanocapsules
/ chemistry
Nitric Oxide
/ chemistry
Nitric Oxide Synthase Type III
/ metabolism
Polymers
/ chemistry
Polyphenols
/ chemistry
Quercetin
/ chemistry
Reactive Oxygen Species
/ chemistry
Resveratrol
/ chemistry
ROS
atherosclerosis
cherry extracts
curcumin
heart failure
hypertension
nitric oxide
polymeric nanoparticles
quercetin
resveratrol
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
22 Jul 2020
22 Jul 2020
Historique:
received:
31
05
2020
revised:
16
07
2020
accepted:
17
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
18
3
2021
Statut:
epublish
Résumé
Numerous studies document an increased production of reactive oxygen species (ROS) with a subsequent decrease in nitric oxide (NO) bioavailability in different cardiovascular diseases, including hypertension, atherosclerosis, and heart failure. Many natural polyphenols have been demonstrated to decrease ROS generation and/or to induce the endogenous antioxidant enzymatic defense system. Moreover, different polyphenolic compounds have the ability to increase the activity/expression of endothelial nitric oxide synthase (eNOS) with a subsequent enhancement of NO generation. However, as a result of low absorption and bioavailability of natural polyphenols, the beneficial effects of these substances are very limited. Recent progress in delivering polyphenols to the targeted tissues revealed new possibilities for the use of polymeric nanoparticles in increasing the efficiency and reducing the degradability of natural polyphenols. This review focuses on the effects of different natural polyphenolic substances, especially resveratrol, quercetin, curcumin, and cherry extracts, and their ability to bind to polymeric nanoparticles, and summarizes the effects of polyphenol-loaded nanoparticles, mainly in the cardiovascular system.
Identifiants
pubmed: 32707934
pii: molecules25153322
doi: 10.3390/molecules25153322
pmc: PMC7435870
pii:
doi:
Substances chimiques
Antioxidants
0
Biological Products
0
Nanocapsules
0
Polymers
0
Polyphenols
0
Reactive Oxygen Species
0
Nitric Oxide
31C4KY9ESH
Quercetin
9IKM0I5T1E
Nitric Oxide Synthase Type III
EC 1.14.13.39
Curcumin
IT942ZTH98
Resveratrol
Q369O8926L
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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