A Novel Methoxybenzyl 5-Nitroacridone Derivative Effectively Triggers G1 Cell Cycle Arrest in Chronic Myelogenous Leukemia K562 Cells by Inhibiting CDK4/6-Mediated Phosphorylation of Rb.
Antineoplastic Agents
/ pharmacology
Apoptosis
/ drug effects
Caspases
/ metabolism
Cell Proliferation
/ drug effects
Chromatography, Liquid
Cyclin-Dependent Kinase 4
/ chemistry
Cyclin-Dependent Kinase 6
/ metabolism
G1 Phase Cell Cycle Checkpoints
/ drug effects
Humans
K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/ drug therapy
Mass Spectrometry
Metabolomics
Molecular Docking Simulation
Phosphorylation
Retinoblastoma Protein
/ metabolism
Signal Transduction
/ drug effects
CDK4/6
acridone derivatives
anti-leukemia mechanism
chronic myeloid leukemia
metabolomics
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Jul 2020
18 Jul 2020
Historique:
received:
29
06
2020
revised:
16
07
2020
accepted:
17
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
6
3
2021
Statut:
epublish
Résumé
Chronic myeloid leukemia (CML) is a malignant tumor caused by the abnormal proliferation of hematopoietic stem cells. Among a new series of acridone derivatives previously synthesized, it was found that the methoxybenzyl 5-nitroacridone derivative
Identifiants
pubmed: 32708403
pii: ijms21145077
doi: 10.3390/ijms21145077
pmc: PMC7403985
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Retinoblastoma Protein
0
CDK4 protein, human
EC 2.7.11.22
CDK6 protein, human
EC 2.7.11.22
Cyclin-Dependent Kinase 4
EC 2.7.11.22
Cyclin-Dependent Kinase 6
EC 2.7.11.22
Caspases
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the National Key Research and Development Program of China
ID : 2018YFC0310900
Organisme : the Natural Science Foundation of Ningbo City
ID : 2018A610410
Organisme : Foundation of Ningbo University for Grant
ID : XYL18004, XYL20023
Organisme : the National 111 Project of China
ID : D16013
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