Qualifying the T-2 Toxin-Degrading Properties of Seven Microbes with Zebrafish Embryo Microinjection Method.
Rhodococcus erythropolis
Trichothecene
biodegradation
metabolites
phenotype
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
18 07 2020
18 07 2020
Historique:
received:
10
06
2020
revised:
10
07
2020
accepted:
14
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
3
3
2021
Statut:
epublish
Résumé
T-2 mycotoxin degradation and detoxification efficiency of seven bacterial strains were investigated with zebrafish microinjection method in three steps ((1) determination of mycotoxin toxicity baseline, (2) examination of bacterial metabolites toxicity, (3) identification of degradation products toxicity). Toxicity of T-2 was used as a baseline of toxic effects, bacterial metabolites of strains as control of bacterial toxicity and degradation products of toxin as control of biodegradation were injected into one-cell stage embryos in the same experiment. The results of in vivo tests were checked and supplemented with UHPLC-MS/MS measurement of T-2 concentration of samples. Results showed that the
Identifiants
pubmed: 32708466
pii: toxins12070460
doi: 10.3390/toxins12070460
pmc: PMC7405011
pii:
doi:
Substances chimiques
T-2 Toxin
I3FL5NM3MO
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Nemzeti Kutatási, Fejlesztési és Innovaciós Alap
ID : NVKP_16-1-2016-0009, NVKP_16-1-2016-0035, EFOP-3.6.3-VEKOP-16-2017-00008
Pays : International
Organisme : Ministry for Innovation and Technology, Hungary
ID : NKFIH-831-10/2019
Pays : International
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