Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model.
Animals
Biomarkers
Carcinoma, Pancreatic Ductal
/ etiology
Cell Transformation, Neoplastic
/ chemically induced
Disease Models, Animal
Disease Progression
Disease Susceptibility
Gene Expression
Immunohistochemistry
Mice
Mucins
/ genetics
Multigene Family
Pancreatic Neoplasms
/ etiology
Proto-Oncogene Proteins p21(ras)
/ metabolism
Tamoxifen
/ adverse effects
Transcription Factors
Inducible KC (iKC) mouse model
Mucin
Pancreatic ductal adenocarcinoma (PDAC)
Journal
Biology open
ISSN: 2046-6390
Titre abrégé: Biol Open
Pays: England
ID NLM: 101578018
Informations de publication
Date de publication:
07 09 2020
07 09 2020
Historique:
pubmed:
28
7
2020
medline:
2
10
2021
entrez:
26
7
2020
Statut:
epublish
Résumé
Pancreatic cancer (PC) is acquired postnatally; to mimic this scenario, we developed an inducible Kras
Identifiants
pubmed: 32709695
pii: bio.052878
doi: 10.1242/bio.052878
pmc: PMC7502593
pii:
doi:
Substances chimiques
Biomarkers
0
KRAS protein, human
0
Mucins
0
Transcription Factors
0
Tamoxifen
094ZI81Y45
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R01 CA183459
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA195586
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA206444
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA238953
Pays : United States
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsS.K.B. is one of the co-founders for the Sanguine Diagnostics and Therapeutics, Inc. Other co-authors have no competing interests.
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