The abnormal reward network associated with insomnia severity and depression in chronic insomnia disorder.
Depression
Functional connectivity
Insomnia
Reward network
Journal
Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
pubmed:
28
7
2020
medline:
28
4
2021
entrez:
26
7
2020
Statut:
ppublish
Résumé
Previous research has shown that acute sleep deprivation can influence the reward networks. However, it is unclear whether and how the intrinsic reward network is altered in chronic insomnia disorder (CID). In the present study, we aimed to investigate whether the reward network is altered in patients with CID using resting-state functional magnetic resonance imaging (fMRI) data. Forty-two patients with CID and 33 healthy controls (HCs) were enrolled and underwent resting-state fMRI. Nucleus accumbens (NAc) - based functional connectivity (NAFC) was evaluated to explore the differences in the reward network between the CID and HC groups. Pearson correlation analysis was used to evaluate the clinical significance of altered NAFC networks. Compared to those in the HC group, increased NAFC was found in the salience and limbic networks, while decreased NAFC was found in the default mode network (DMN) and within the reward circuit in patients with CID. In addition, decreased FC between the NAc and DMN was associated with insomnia severity, while NAFC within the reward network was associated with depression symptoms in patients with CID. These findings showed that the reward network is dysfunctional and associated with depression symptom in patients with CID. Future studies of CID should consider both insomnia and depression symptoms to disentangle the role of insomnia and depression in the relationship under study.
Identifiants
pubmed: 32710331
doi: 10.1007/s11682-020-00310-w
pii: 10.1007/s11682-020-00310-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1033-1042Subventions
Organisme : National Natural Science Foundation of China-Yunnan Joint Fund
ID : 81303057,81503670, 81373560, and 81603682
Organisme : Science and Technology Department of Sichuan Province
ID : 2018JY0249, 20YYJC0034
Organisme : Chengdu Medical Research Project
ID : 2019115
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