Epigenetics
SIR2
gene expression noise
silencing
viability
Journal
G3 (Bethesda, Md.)
ISSN: 2160-1836
Titre abrégé: G3 (Bethesda)
Pays: England
ID NLM: 101566598
Informations de publication
Date de publication:
02 09 2020
02 09 2020
Historique:
pubmed:
31
7
2020
medline:
22
6
2021
entrez:
31
7
2020
Statut:
epublish
Résumé
Chromatin structure clearly modulates gene expression noise, but the reverse influence has never been investigated, namely how the cell-to-cell expression heterogeneity of chromatin modifiers may generate variable rates of epigenetic modification. Sir2 is a well-characterized histone deacetylase of the Sirtuin family. It strongly influences chromatin silencing, especially at telomeres, subtelomeres and rDNA. This ability to influence epigenetic landscapes makes it a good model to study the largely unexplored interplay between gene expression noise and other epigenetic processes leading to phenotypic diversification. Here, we addressed this question by investigating whether noise in the expression of
Identifiants
pubmed: 32727919
pii: g3.120.401589
doi: 10.1534/g3.120.401589
pmc: PMC7466964
doi:
Substances chimiques
Saccharomyces cerevisiae Proteins
0
Silent Information Regulator Proteins, Saccharomyces cerevisiae
0
URA3 protein, S cerevisiae
0
SIR2 protein, S cerevisiae
EC 3.5.1.-
Sirtuin 2
EC 3.5.1.-
Sirtuins
EC 3.5.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3435-3443Informations de copyright
Copyright © 2020 Liu et al.
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