Poplar Propolis Ethanolic Extract Reduces Body Weight Gain and Glucose Metabolism Disruption in High-Fat Diet-Fed Mice.
3T3-L1 Cells
Adipose Tissue
/ drug effects
Animals
Anti-Obesity Agents
/ chemistry
Diet, High-Fat
/ adverse effects
Ethanol
/ chemistry
Gene Expression Regulation
/ drug effects
Glucose
/ metabolism
Male
Mice
Mice, Inbred C57BL
NF-E2-Related Factor 2
/ genetics
Obesity
/ etiology
Plant Extracts
/ chemistry
Polyphenols
/ analysis
Populus
Propolis
/ chemistry
Weight Gain
/ drug effects
NRF2
adipose tissue
insulin resistance
obesity
propolis
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
23
03
2020
revised:
07
07
2020
pubmed:
31
7
2020
medline:
3
8
2021
entrez:
31
7
2020
Statut:
ppublish
Résumé
Current evidence supports the beneficial effect of polyphenols on the management of obesity and associated comorbidities. This is the case for propolis, a polyphenol-rich substance produced by bees. The aim of the present study is to evaluate the effect of a poplar propolis ethanolic extract (PPEE) on obesity and glucose homeostasis, and to unveil its putative molecular mechanisms of action. Male high-fat (HF) diet-fed mice are administered PPEE for 12 weeks. PPEE supplementation reduces the HF-mediated adiposity index, adipocyte hypertrophy, and body weight gain. It also improves HOMA-IR and fasting glucose levels. Gene expression profiling of adipose tissue (AT) shows an induction of mRNA related to lipid catabolism and mitochondrial biogenesis and inhibition of mRNA coding for inflammatory markers. Interestingly, several Nrf2-target genes are induced in AT following administration of PPEE. The ability of PPEE to induce the expression of Nrf2-target genes is studied in adipocytes. PPEE is found to transactivate the Nrf2 response element and the Nrf2 DNA-binding, suggesting that part of the effect of PPEE can be mediated by Nrf2. PPEE supplementation may represent an interesting preventive strategy to tackle the onset of obesity and associated metabolic disorders.
Identifiants
pubmed: 32729164
doi: 10.1002/mnfr.202000275
doi:
Substances chimiques
Anti-Obesity Agents
0
NF-E2-Related Factor 2
0
Nfe2l2 protein, mouse
0
Plant Extracts
0
Polyphenols
0
Ethanol
3K9958V90M
Propolis
9009-62-5
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000275Informations de copyright
© 2020 Wiley-VCH GmbH.
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