X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 11 2020
01 11 2020
Historique:
received:
06
05
2020
revised:
24
06
2020
accepted:
27
07
2020
pubmed:
1
8
2020
medline:
27
11
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
Biological sex profoundly conditions organismal development and physiology, imposing wide-ranging effects on cell signaling, metabolism, and immune response. These effects arise from sex-specified differences in hormonal exposure, and from intrinsic genetic and epigenetic differences associated with the presence of an XX versus XY chromosomal complement. In addition, biological sex is now recognized to be a determinant of the incidence, presentation, and therapeutic response of multiple forms of cancer, including cancers not specifically associated with male or female anatomy. Although multiple factors contribute to sex-based differences in cancer, a growing body of research emphasizes a role for differential activity of X- and Y-linked tumor-suppressor genes in males and females. Among these, the X-linked
Identifiants
pubmed: 32732223
pii: 1078-0432.CCR-20-1741
doi: 10.1158/1078-0432.CCR-20-1741
pmc: PMC7642178
mid: NIHMS1615496
doi:
Substances chimiques
Minor Histocompatibility Antigens
0
Nuclear Proteins
0
UTY protein, human
0
Histone Demethylases
EC 1.14.11.-
KDM5C protein, human
EC 1.14.11.-
KDM5D protein, human
EC 1.14.11.-
KDM6A protein, human
EC 1.14.11.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5567-5578Subventions
Organisme : NCI NIH HHS
ID : P30 CA006927
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK108195
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA228187
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK108195
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
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