Improved HLA-based prediction of coeliac disease identifies two novel genetic interactions.
Journal
European journal of human genetics : EJHG
ISSN: 1476-5438
Titre abrégé: Eur J Hum Genet
Pays: England
ID NLM: 9302235
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
07
06
2019
accepted:
07
07
2020
revised:
30
06
2020
pubmed:
1
8
2020
medline:
3
6
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
Human Leucocyte Antigen (HLA) testing is useful in the clinical work-up of coeliac disease (CD) with high negative but low positive predictive value. We construct a genomic risk score (GRS) using HLA risk genotypes to improve CD prediction and guide exclusion criteria. Imputed HLA genotypes for five European CD case-control GWAS (n > 15,000) were used to construct and validate an interpretable HLA-based risk model (HDQ
Identifiants
pubmed: 32733071
doi: 10.1038/s41431-020-0700-2
pii: 10.1038/s41431-020-0700-2
pmc: PMC7785002
doi:
Substances chimiques
HLA Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1743-1752Références
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