Monitoring the Interaction of α-Synuclein with Calcium Ions through Exclusively Heteronuclear Nuclear Magnetic Resonance Experiments.
13C detection
IDPs
calcium binding
side chains
water exchange
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
12 10 2020
12 10 2020
Historique:
received:
06
06
2020
revised:
14
07
2020
pubmed:
1
8
2020
medline:
19
3
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
Many properties of intrinsically disordered proteins (IDPs), or protein regions (IDRs), are modulated by the nature of amino acid side chains as well as by local solvent exposure. We propose a set of exclusively heteronuclear NMR experiments to investigate these features in different experimental conditions that are relevant for physiological function. The proposed approach is generally applicable to many IDPs/IDRs whose assignment is available in the Biological Magnetic Resonance Bank (BMRB) to investigate how their properties are modulated by different, physiologically relevant conditions. The experiments, tested on α-synuclein, are then used to investigate how α-synuclein senses Ca
Identifiants
pubmed: 32735376
doi: 10.1002/anie.202008079
doi:
Substances chimiques
Carbon Isotopes
0
Ions
0
alpha-Synuclein
0
Water
059QF0KO0R
Carbon-13
FDJ0A8596D
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18537-18545Informations de copyright
© 2020 Wiley-VCH GmbH.
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