The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver.
DNA damage responses
POSTN-ITGAV interaction
fetal liver
fetal liver niche
hematopoietic stem cells
outside-in integrin signaling
Journal
Stem cell reports
ISSN: 2213-6711
Titre abrégé: Stem Cell Reports
Pays: United States
ID NLM: 101611300
Informations de publication
Date de publication:
11 08 2020
11 08 2020
Historique:
received:
18
10
2019
revised:
25
06
2020
accepted:
25
06
2020
pubmed:
1
8
2020
medline:
3
6
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
We earlier showed that outside-in integrin signaling through POSTN-ITGAV interaction plays an important role in regulating adult hematopoietic stem cell (HSC) quiescence. Here, we show that Itgav deletion results in increased frequency of phenotypic HSCs in fetal liver (FL) due to faster proliferation. Systemic deletion of Postn led to increased proliferation of FL HSCs, albeit without any loss of stemness, unlike Vav-Itgav
Identifiants
pubmed: 32735820
pii: S2213-6711(20)30243-5
doi: 10.1016/j.stemcr.2020.06.022
pmc: PMC7419718
pii:
doi:
Substances chimiques
Cell Adhesion Molecules
0
Integrin alphaV
0
Integrin beta3
0
Postn protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
340-357Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : DBT-Wellcome Trust India Alliance
ID : IA/I/15/2/502061
Pays : India
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
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