Identification of novel Urotensin-II receptor antagonists with potent inhibition of U-II induced pressor response in mice.
Animals
Antihypertensive Agents
/ pharmacology
Blood Pressure
/ drug effects
CHO Cells
Calcium
/ metabolism
Cricetinae
Cricetulus
Dose-Response Relationship, Drug
Heart Failure
/ drug therapy
Humans
Hypertension
/ chemically induced
Mice
Mice, Inbred C57BL
Receptors, G-Protein-Coupled
/ antagonists & inhibitors
Small Molecule Libraries
Structure-Activity Relationship
Urotensins
/ antagonists & inhibitors
Binding assay
Calcium assay
Chronic heart failure
Mouse pressor response
Urotensin II receptor Antagonist
Vasoconstriction
Journal
European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354
Informations de publication
Date de publication:
05 Nov 2020
05 Nov 2020
Historique:
received:
11
10
2019
revised:
08
07
2020
accepted:
20
07
2020
pubmed:
4
8
2020
medline:
15
5
2021
entrez:
4
8
2020
Statut:
ppublish
Résumé
Urotensin II (U-II) has been found to be one of the most potent vasoconstrictor (Ames et al., 1999; Bohm et al., 2002) reported till date. U-II exerts its response via activation of a G-protein coupled receptor, Urotensin II receptor(UT). Binding of U-II to UT leads to an instant increase in the inositol phosphate turnover and intracellular Ca
Identifiants
pubmed: 32745605
pii: S0014-2999(20)30483-0
doi: 10.1016/j.ejphar.2020.173391
pii:
doi:
Substances chimiques
Antihypertensive Agents
0
Receptors, G-Protein-Coupled
0
Small Molecule Libraries
0
Urotensins
0
urotensin II receptor, mouse
0
urotensin II
9047-55-6
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173391Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.