Epigenetic Silencing of LMX1A Contributes to Cancer Progression in Lung Cancer Cells.

Carcinoma, Non-Small-Cell Lung / genetics Cell Line, Tumor DNA Methylation Epigenesis, Genetic Epithelial-Mesenchymal Transition Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Humans LIM-Homeodomain Proteins / genetics Lung Neoplasms / genetics Transcription Factors / genetics
DNA methylation LMX1A epithelial mesenchymal transition lung cancer tumor suppressor

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
30 Jul 2020
Historique:
received: 19 06 2020
revised: 16 07 2020
accepted: 27 07 2020
entrez: 6 8 2020
pubmed: 6 8 2020
medline: 23 2 2021
Statut: epublish

Résumé

Epigenetic modification is considered a major mechanism of the inactivation of tumor suppressor genes that finally contributes to carcinogenesis. LIM homeobox transcription factor 1α (

Identifiants

DOI: 10.3390/ijms21155425 PMID: 32751497 PMC: PMC7432919
pubmed: 32751497
pii: ijms21155425
doi: 10.3390/ijms21155425
pmc: PMC7432919
pii:
doi:

Substances chimiques

LIM-Homeodomain Proteins 0
LMX1A protein, human 0
Transcription Factors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : the Ministry of Science and Technology, Taiwan
ID : 105-2320-B-016-017-MY3

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Auteurs

Ti-Hui Wu (TH)

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan.
Division of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
ORCID: 0000-0002-2627-040X

Shan-Yueh Chang (SY)

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan.
Division of Pulmonary and Critical Care, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
ORCID: 0000-0001-8944-174X

Yu-Lueng Shih (YL)

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan.
Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
ORCID: 0000-0003-4629-4393

Chih-Feng Chian (CF)

Division of Pulmonary and Critical Care, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.

Hung Chang (H)

Division of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.

Ya-Wen Lin (YW)

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan.
Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei 11490, Taiwan.
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan.
ORCID: 0000-0002-1639-7941

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Epigenetic Silencing of LMX1A Contributes to...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Epigenetic Silencing of LMX1A Contributes to...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Epigenetic Silencing of LMX1A Contributes to...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenetic Silencing of LMX1A Contributes to...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Transition épithélio-mésenchymateuse › Epigenetic Silencing of LMX1A Contributes to...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Epigenetic Silencing of LMX1A Contributes to...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes suppresseurs de tumeur › Epigenetic Silencing of LMX1A Contributes to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenetic Silencing of LMX1A Contributes to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines à domaine LIM › Protéines à homéodomaine LIM › Epigenetic Silencing of LMX1A Contributes to...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Epigenetic Silencing of LMX1A Contributes to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Epigenetic Silencing of LMX1A Contributes to...