Rescue of oxytocin response and social behaviour in a mouse model of autism.

Animals Autistic Disorder / metabolism Cell Adhesion Molecules, Neuronal / deficiency Disease Models, Animal Eukaryotic Initiation Factor-4E / metabolism Male Membrane Proteins / deficiency Mice Mice, Inbred C57BL Mice, Knockout Mitogen-Activated Protein Kinases / metabolism Nerve Tissue Proteins / deficiency Neurons / drug effects Oxytocin / metabolism Phosphorylation / drug effects Protein Biosynthesis / drug effects RNA, Messenger / genetics Signal Transduction / drug effects Social Behavior Ventral Tegmental Area / cytology

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
08 2020
Historique:
received: 20 05 2019
accepted: 25 05 2020
pubmed: 8 8 2020
medline: 15 9 2020
entrez: 8 8 2020
Statut: ppublish

Résumé

A fundamental challenge in developing treatments for autism spectrum disorders is the heterogeneity of the condition. More than one hundred genetic mutations confer high risk for autism, with each individual mutation accounting for only a small fraction of cases

Identifiants

DOI: 10.1038/s41586-020-2563-7 PMID: 32760004 PMC: PMC7116741
pubmed: 32760004
doi: 10.1038/s41586-020-2563-7
pii: 10.1038/s41586-020-2563-7
pmc: PMC7116741
mid: EMS114606
doi:

Substances chimiques

Cell Adhesion Molecules, Neuronal 0
Eukaryotic Initiation Factor-4E 0
Membrane Proteins 0
Nerve Tissue Proteins 0
RNA, Messenger 0
neuroligin 3 0
Oxytocin 50-56-6
Mitogen-Activated Protein Kinases EC 2.7.11.24

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

252-256

Subventions

Organisme : Swiss National Science Foundation
ID : 140944
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 160319
Pays : Switzerland
Organisme : European Research Council
Pays : International

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Références

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Auteurs

Hanna Hörnberg (H)

Biozentrum of the University of Basel, Basel, Switzerland.

Enrique Pérez-Garci (E)

Department of Biomedicine, University of Basel, Basel, Switzerland.

Dietmar Schreiner (D)

Biozentrum of the University of Basel, Basel, Switzerland.

Laetitia Hatstatt-Burklé (L)

Biozentrum of the University of Basel, Basel, Switzerland.

Fulvio Magara (F)

Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.

Stephane Baudouin (S)

Neuroscience Division, School of Biosciences, Cardiff University, Cardiff, UK.
Stalicla, Geneva, Switzerland.

Alex Matter (A)

Experimental Drug Development Centre, Singapore, Singapore.

Kassoum Nacro (K)

Experimental Drug Development Centre, Singapore, Singapore.
ORCID: 0000-0002-3291-0215

Eline Pecho-Vrieseling (E)

Department of Biomedicine, University of Basel, Basel, Switzerland.

Peter Scheiffele (P)

Biozentrum of the University of Basel, Basel, Switzerland. peter.scheiffele@unibas.ch.
ORCID: 0000-0002-9516-9399

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Rescue of oxytocin response and social...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Trouble autistique › Rescue of oxytocin response and social...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Molécules d'adhérence cellulaire neuronale › Rescue of oxytocin response and social...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Rescue of oxytocin response and social...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines ribosomiques › Facteurs initiation chaîne peptidique › Facteurs d'initiation eucaryotes › Facteur-4F d'initiation eucaryote › Facteur-4E d'initiation eucaryote › Rescue of oxytocin response and social...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Rescue of oxytocin response and social...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Rescue of oxytocin response and social...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Rescue of oxytocin response and social...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Rescue of oxytocin response and social...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Rescue of oxytocin response and social...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Rescue of oxytocin response and social...
questionsmedicales.fr › Cellules › Neurones › Rescue of oxytocin response and social...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones post-hypophysaires › Ocytocine › Rescue of oxytocin response and social...
questionsmedicales.fr › Métabolisme › Phosphorylation › Rescue of oxytocin response and social...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Biosynthèse des protéines › Rescue of oxytocin response and social...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Rescue of oxytocin response and social...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Rescue of oxytocin response and social...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement social › Rescue of oxytocin response and social...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Tegmentum du mésencéphale › Aire tegmentale ventrale › Rescue of oxytocin response and social...