First identification of a Brucella abortus biovar 4 strain from yak in Tibet, China.
Brucella abortus biovar 4
Brucellosis
Tibet
Yak
Journal
Veterinary microbiology
ISSN: 1873-2542
Titre abrégé: Vet Microbiol
Pays: Netherlands
ID NLM: 7705469
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
18
12
2019
revised:
29
05
2020
accepted:
09
06
2020
entrez:
10
8
2020
pubmed:
10
8
2020
medline:
8
6
2021
Statut:
ppublish
Résumé
Brucellosis is one of the major zoonotic diseases in the world. In China, understanding on its causative agent Brucella is still limited. Recently, we isolated a Brucella strain XZ19-1 from yak in Lhasa, Tibet. Phenotypical characterization proved that it belongs to B. abortus biovar 4, a biotype that has never been reported in China. MLVA-16 genotyping revealed a novel profile (4-5-3-12-2-2-3-3-8-32-8-5-4-3-3-3) in this strain, while MLST sequence typing demonstrated that it belongs to ST 71. Furthermore, the whole genome of XZ19-1 strain was sequenced. Subsequent phylogenetic analysis demonstrated that XZ19-1was genetically more closely related to B. abortus strains originated from European countries rather than to those collected from China previously. Isolation and identification of XZ19-1 strain may thus indicate a unique Brucella lineage existing in Qing-Tibet plateau. These findings will help to improve the diagnosis and epidemiological studies of brucellosis in animals and human in this part of China.
Identifiants
pubmed: 32768205
pii: S0378-1135(19)31489-0
doi: 10.1016/j.vetmic.2020.108751
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108751Informations de copyright
Copyright © 2020. Published by Elsevier B.V.