Genesis and spread of multiple reassortants during the 2016/2017 H5 avian influenza epidemic in Eurasia.
emerging infectious diseases
highly pathogenic avian influenza
phylogenetic analysis
poultry
wild birds
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
25 08 2020
25 08 2020
Historique:
pubmed:
10
8
2020
medline:
29
10
2020
entrez:
10
8
2020
Statut:
ppublish
Résumé
Highly pathogenic avian influenza (HPAI) viruses of the H5 A/goose/Guangdong/1/96 lineage can cause severe disease in poultry and wild birds, and occasionally in humans. In recent years, H5 HPAI viruses of this lineage infecting poultry in Asia have spilled over into wild birds and spread via bird migration to countries in Europe, Africa, and North America. In 2016/2017, this spillover resulted in the largest HPAI epidemic on record in Europe and was associated with an unusually high frequency of reassortments between H5 HPAI viruses and cocirculating low-pathogenic avian influenza viruses. Here, we show that the seven main H5 reassortant viruses had various combinations of gene segments 1, 2, 3, 5, and 6. Using detailed time-resolved phylogenetic analysis, most of these gene segments likely originated from wild birds and at dates and locations that corresponded to their hosts' migratory cycles. However, some gene segments in two reassortant viruses likely originated from domestic anseriforms, either in spring 2016 in east China or in autumn 2016 in central Europe. Our results demonstrate that, in addition to domestic anseriforms in Asia, both migratory wild birds and domestic anseriforms in Europe are relevant sources of gene segments for recent reassortant H5 HPAI viruses. The ease with which these H5 HPAI viruses reassort, in combination with repeated spillovers of H5 HPAI viruses into wild birds, increases the risk of emergence of a reassortant virus that persists in wild bird populations yet remains highly pathogenic for poultry.
Identifiants
pubmed: 32769208
pii: 2001813117
doi: 10.1073/pnas.2001813117
pmc: PMC7456104
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20814-20825Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/20002173
Pays : United Kingdom
Investigateurs
Samantha J Lycett
(SJ)
Anne Pohlmann
(A)
Christoph Staubach
(C)
Valentina Caliendo
(V)
Steven van Borm
(S)
Andrew Breed
(A)
Francois-Xavier Briand
(FX)
Ian Brown
(I)
Ádám Dán
(Á)
Thomas DeLiberto
(T)
Sophie von Dobschuetz
(S)
Ron Fouchier
(R)
Marius Gilbert
(M)
Sarah Hill
(S)
Charlotte Kristiane Hjulsager
(CK)
Hon Ip
(H)
Marion Koopmans
(M)
Lars Erik Larsen
(LE)
Dong-Hun Lee
(DH)
Mahmoud Mohamed Naguib
(MM)
Isabella Monne
(I)
Oliver Pybus
(O)
Andrew Ramey
(A)
Vladimir Savic
(V)
Kirill Sharshov
(K)
Alexander Shestopalov
(A)
Chang-Seon Song
(CS)
Mieke Steensels
(M)
David Swayne
(D)
Edyta Świętoń
(E)
XiuFeng Wan
(X)
Siamak Zohari
(S)
Mark Woolhouse
(M)
Martin Beer
(M)
Thijs Kuiken
(T)
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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