New Deoxyribozymes for the Native Ligation of RNA.
DNA catalysis
RNA ligation
deoxyribozyme
in vitro selection
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
11 Aug 2020
11 Aug 2020
Historique:
received:
29
07
2020
revised:
07
08
2020
accepted:
10
08
2020
entrez:
16
8
2020
pubmed:
17
8
2020
medline:
4
3
2021
Statut:
epublish
Résumé
Deoxyribozymes (DNAzymes) are small, synthetic, single-stranded DNAs capable of catalyzing chemical reactions, including RNA ligation. Herein, we report a novel class of RNA ligase deoxyribozymes that utilize 5'-adenylated RNA (5'-AppRNA) as the donor substrate, mimicking the activated intermediates of protein-catalyzed RNA ligation. Four new DNAzymes were identified by in vitro selection from an N
Identifiants
pubmed: 32796587
pii: molecules25163650
doi: 10.3390/molecules25163650
pmc: PMC7465978
pii:
doi:
Substances chimiques
DNA, Catalytic
0
RNA
63231-63-0
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : H2020 European Research Council
ID : 682586
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