RNA-Catalyzed Cross-Chiral Polymerization of RNA.

Biocatalysis Nucleic Acid Conformation Polymerization RNA / biosynthesis

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
09 09 2020
Historique:
pubmed: 18 8 2020
medline: 20 4 2021
entrez: 18 8 2020
Statut: ppublish

Résumé

Biology relies almost exclusively on homochiral building blocks to drive the processes of life. Yet cross-chiral interactions can occur between macromolecules of the opposite handedness, including a previously described polymerase ribozyme that catalyzes the template-directed synthesis of enantio-RNA. The present study sought to optimize and generalize this activity, employing

Identifiants

DOI: 10.1021/jacs.0c05635 PMID: 32805113
pubmed: 32805113
doi: 10.1021/jacs.0c05635
doi:

Substances chimiques

RNA 63231-63-0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

15331-15339

Auteurs

Katrina F Tjhung (KF)

The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, United States.

Jonathan T Sczepanski (JT)

Department of Chemistry, Texas A&M University, P.O. Box 30012, College Station, Texas 77842, United States.
ORCID: 0000-0002-9275-2597

Eric R Murtfeldt (ER)

The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, United States.

Gerald F Joyce (GF)

The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, United States.
ORCID: 0000-0003-0603-2874

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Biocatalyse › RNA-Catalyzed Cross-Chiral Polymerization of RNA.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › RNA-Catalyzed Cross-Chiral Polymerization of RNA.
questionsmedicales.fr › Phénomènes chimiques › Polymérisation › RNA-Catalyzed Cross-Chiral Polymerization of RNA.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › RNA-Catalyzed Cross-Chiral Polymerization of RNA.