Hair cortisol and dehydroepiandrosterone concentrations: Associations with executive function in early childhood.

Child Child, Preschool Dehydroepiandrosterone Executive Function / physiology Humans Hydrocortisone Hypothalamo-Hypophyseal System Pituitary-Adrenal System
Children Chronic stress Cortisol Dehydroepiandrosterone Executive function

Journal

Biological psychology
ISSN: 1873-6246
Titre abrégé: Biol Psychol
Pays: Netherlands
ID NLM: 0375566

Informations de publication

Date de publication:
09 2020
Historique:
received: 12 06 2019
revised: 31 07 2020
accepted: 04 08 2020
pubmed: 18 8 2020
medline: 11 2 2021
entrez: 18 8 2020
Statut: ppublish

Résumé

Chronic stress during childhood negatively impacts cognition and physical and mental health. Exposure to stressors over time can cause hypothalamic-pituitary-adrenal (HPA) axis dysregulation, leading to abnormal stress hormone levels, which can be reflected in hair cortisol concentration (HCC) and hair dehydroepiandrosterone (DHEA) concentration. Although the use of HCC and DHEA to measure chronic stress in children is increasing, their effects on cognition (as indexed by executive function) remain unexplored. Accordingly, we aimed to investigate the associations of HCC, DHEA, and their ratio with measures of executive function (cognitive flexibility and working memory) in a sample of kindergarten children (N=100). We found that the expected negative association between HCC and working memory approached significance, and DHEA was significantly and positively related to cognitive flexibility. We discuss possible interpretations of our findings. Our results suggest promising areas for future investigation and encourage further exploration into HCC and DHEA as measures of chronic stress.

Identifiants

DOI: 10.1016/j.biopsycho.2020.107946 PMID: 32805299 PMC: PMC7530148
pubmed: 32805299
pii: S0301-0511(20)30106-X
doi: 10.1016/j.biopsycho.2020.107946
pmc: PMC7530148
mid: NIHMS1622362
pii:
doi:

Substances chimiques

Dehydroepiandrosterone 459AG36T1B
Hydrocortisone WI4X0X7BPJ

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

107946

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD096261
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD094834
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD086168
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD078351
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD044073
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD052120
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

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Auteurs

Ella-Marie P Hennessey (EP)

Department of Psychiatry and Weill Institute for Neurosciences and Dyslexia Center, University of California San Francisco, 401 Parnassus Ave., San Francisco, CA, 94143, USA; Multi-University Precision Learning Center, 401 Parnassus Ave., San Francisco, CA, 94143, USA; Department of Psychology, University of Denver, 2155 S. Race Street, Denver, CO, 80210, USA.

Olga Kepinska (O)

Department of Psychiatry and Weill Institute for Neurosciences and Dyslexia Center, University of California San Francisco, 401 Parnassus Ave., San Francisco, CA, 94143, USA.

Stephanie L Haft (SL)

Department of Psychiatry and Weill Institute for Neurosciences and Dyslexia Center, University of California San Francisco, 401 Parnassus Ave., San Francisco, CA, 94143, USA; Department of Psychology, University of California Berkeley, 2121 Berkeley Way, Berkeley, CA, 94704, USA.

Megan Chan (M)

Department of Psychiatry and Weill Institute for Neurosciences and Dyslexia Center, University of California San Francisco, 401 Parnassus Ave., San Francisco, CA, 94143, USA; Multi-University Precision Learning Center, 401 Parnassus Ave., San Francisco, CA, 94143, USA; Department of Psychology, University of California Berkeley, 2121 Berkeley Way, Berkeley, CA, 94704, USA.

Isabel Sunshine (I)

Department of Psychiatry and Weill Institute for Neurosciences and Dyslexia Center, University of California San Francisco, 401 Parnassus Ave., San Francisco, CA, 94143, USA; Multi-University Precision Learning Center, 401 Parnassus Ave., San Francisco, CA, 94143, USA.

Chloe Jones (C)

Brain Imaging Research Center (BIRC) & Department of Psychological Sciences, University of Connecticut, 850 Bolton Road, Storrs, CT, 06269, USA.

Roeland Hancock (R)

Brain Imaging Research Center (BIRC) & Department of Psychological Sciences, University of Connecticut, 850 Bolton Road, Storrs, CT, 06269, USA.

Fumiko Hoeft (F)

Department of Psychiatry and Weill Institute for Neurosciences and Dyslexia Center, University of California San Francisco, 401 Parnassus Ave., San Francisco, CA, 94143, USA; Multi-University Precision Learning Center, 401 Parnassus Ave., San Francisco, CA, 94143, USA; Brain Imaging Research Center (BIRC) & Department of Psychological Sciences, University of Connecticut, 850 Bolton Road, Storrs, CT, 06269, USA; Haskins Laboratories, 300 George St #900, New Haven, CT, 06511, USA; Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi Shinjuku, Tokyo, 160-8582 Japan. Electronic address: fumiko.hoeft@uconn.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Hair cortisol and dehydroepiandrosterone...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Hair cortisol and dehydroepiandrosterone...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Déhydroépiandrostérone › Hair cortisol and dehydroepiandrosterone...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Fonction exécutive › Hair cortisol and dehydroepiandrosterone...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hair cortisol and dehydroepiandrosterone...
questionsmedicales.fr › Hormones corticosurrénaliennes › Hydroxycorticostéroïdes › 17-Hydroxycorticostéroïdes › Hydrocortisone › Hair cortisol and dehydroepiandrosterone...
questionsmedicales.fr › Système nerveux › Système neuroendocrinien › Axe hypothalamohypophysaire › Hair cortisol and dehydroepiandrosterone...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Axe hypophyso-surrénalien › Hair cortisol and dehydroepiandrosterone...