Serum potassium in the PARADIGM-HF trial.
Aged
Aminobutyrates
/ therapeutic use
Angiotensin Receptor Antagonists
/ therapeutic use
Angiotensin-Converting Enzyme Inhibitors
/ therapeutic use
Biphenyl Compounds
/ therapeutic use
Drug Combinations
Enalapril
/ therapeutic use
Female
Heart Failure
/ blood
Humans
Male
Potassium
/ blood
Randomized Controlled Trials as Topic
Stroke Volume
/ drug effects
Valsartan
/ therapeutic use
Ventricular Function, Left
Hyperkalaemia
Hypokalaemia
Mineralocorticoid receptor antagonists
Outcomes
Potassium
Sacubitril-valsartan
Journal
European journal of heart failure
ISSN: 1879-0844
Titre abrégé: Eur J Heart Fail
Pays: England
ID NLM: 100887595
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
31
05
2020
revised:
28
07
2020
accepted:
07
08
2020
pubmed:
19
8
2020
medline:
10
6
2021
entrez:
19
8
2020
Statut:
ppublish
Résumé
The associations between potassium level and outcomes, the effect of sacubitril-valsartan on potassium level, and whether potassium level modified the effect of sacubitril-valsartan in patients with heart failure and a reduced ejection fraction were studied in PARADIGM-HF. Several outcomes, including cardiovascular death, sudden death, pump failure death, non-cardiovascular death and heart failure hospitalization, were examined. A total of 8399 patients were randomized to either enalapril or sacubitril-valsartan. Potassium level at randomization and follow-up was examined as a continuous and categorical variable (≤3.5, 3.6-4.0, 4.1-4.9, 5.0-5.4 and ≥5.5 mmol/L) in various statistical models. Hyperkalaemia was defined as K Although both higher and lower potassium levels were independent predictors of cardiovascular death, potassium abnormalities may mainly be markers rather than mediators of risk for death.
Identifiants
pubmed: 32809261
doi: 10.1002/ejhf.1987
pmc: PMC7756204
doi:
Substances chimiques
Aminobutyrates
0
Angiotensin Receptor Antagonists
0
Angiotensin-Converting Enzyme Inhibitors
0
Biphenyl Compounds
0
Drug Combinations
0
Enalapril
69PN84IO1A
Valsartan
80M03YXJ7I
Potassium
RWP5GA015D
sacubitril and valsartan sodium hydrate drug combination
WB8FT61183
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2056-2064Subventions
Organisme : British Heart Foundation
ID : RE/18/6/34217
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
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