Systemic Inflammation Is Associated with Oncological Outcome in Patients with High-Grade Myxofibrosarcoma of the Extremities: A Retrospective Analysis.
Adult
Aged
Aged, 80 and over
Biomarkers
/ blood
C-Reactive Protein
/ analysis
Extremities
/ pathology
Female
Fibrosarcoma
/ blood
Humans
Inflammation
/ blood
Lymphocytes
/ metabolism
Male
Middle Aged
Multivariate Analysis
Myxosarcoma
/ blood
Neoplasm Recurrence, Local
/ pathology
Neutrophils
/ metabolism
Preoperative Period
Prognosis
Retrospective Studies
Soft Tissue Neoplasms
/ blood
Survival Rate
Young Adult
C-reactive protein
Grade
Inflammation
Myxofibrosarcoma
Prognosis
Journal
Oncology research and treatment
ISSN: 2296-5262
Titre abrégé: Oncol Res Treat
Pays: Switzerland
ID NLM: 101627692
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
05
2020
accepted:
14
06
2020
pubmed:
19
8
2020
medline:
27
1
2021
entrez:
19
8
2020
Statut:
ppublish
Résumé
The aim of this retrospective study is to verify whether preoperative systemic inflammatory markers (serum C-reactive protein [CRP] and neutrophil-lymphocyte ratio [NLR]) can help in predicting the disease-specific survival (DSS) and local recurrence (LR) rate in adult patients affected by localized myxofibrosarcoma (MFS) of the extremities. We reviewed 126 adult patients with primary, localized MFS of the limbs. We analyzed DSS and LR. Median age at the time of surgery was 68 years (range 19-92). Median CRP was 0.4 mg/dL and median NLR was 2.8. A worse DSS was found in patients who had preoperative CRP >0.5 mg/dL (p = 0.002) and in those with NLR >3.5 (p < 0.001). In multivariate analysis, tumor size and grade as well as preoperative CRP values and NLR were confirmed to be prognostic factors in terms of DSS. An increased risk of LR was found in multivariate analysis in patients with a tail sign and with high gadolinium enhancement at preoperative MRI. Patients with high preoperative CRP and NLR levels, as well as large and high-grade tumors, might be considered as candidates for additional, more aggressive treatment approaches or more stringent follow-up schedules.
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this retrospective study is to verify whether preoperative systemic inflammatory markers (serum C-reactive protein [CRP] and neutrophil-lymphocyte ratio [NLR]) can help in predicting the disease-specific survival (DSS) and local recurrence (LR) rate in adult patients affected by localized myxofibrosarcoma (MFS) of the extremities.
METHODS
METHODS
We reviewed 126 adult patients with primary, localized MFS of the limbs. We analyzed DSS and LR.
RESULTS
RESULTS
Median age at the time of surgery was 68 years (range 19-92). Median CRP was 0.4 mg/dL and median NLR was 2.8. A worse DSS was found in patients who had preoperative CRP >0.5 mg/dL (p = 0.002) and in those with NLR >3.5 (p < 0.001). In multivariate analysis, tumor size and grade as well as preoperative CRP values and NLR were confirmed to be prognostic factors in terms of DSS. An increased risk of LR was found in multivariate analysis in patients with a tail sign and with high gadolinium enhancement at preoperative MRI.
CONCLUSIONS
CONCLUSIONS
Patients with high preoperative CRP and NLR levels, as well as large and high-grade tumors, might be considered as candidates for additional, more aggressive treatment approaches or more stringent follow-up schedules.
Identifiants
pubmed: 32810863
pii: 000509429
doi: 10.1159/000509429
doi:
Substances chimiques
Biomarkers
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
531-538Informations de copyright
© 2020 S. Karger AG, Basel.