Tracking of Antibiotic Resistance Transfer and Rapid Plasmid Evolution in a Hospital Setting by Nanopore Sequencing.
IMP-8
Nanopore
Nanopore sequencing
Pseudomonas aeruginosa
antimicrobial resistance
genome assembly
horizontal gene transfer
long read
pathoLogic
plasmIDent
plasmid-mediated resistance
plasmids
surveillance studies
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
19 08 2020
19 08 2020
Historique:
entrez:
21
8
2020
pubmed:
21
8
2020
medline:
20
7
2021
Statut:
epublish
Résumé
Infections with multidrug-resistant bacteria often leave limited or no treatment options. The transfer of antimicrobial resistance genes (ARG) carrying plasmids between bacterial species by horizontal gene transfer represents an important mode of expansion of ARGs. Here, we demonstrate the application of Nanopore sequencing in a hospital setting for monitoring transfer and rapid evolution of antibiotic resistance plasmids within and across multiple species. In 2009, we experienced an outbreak with extensively multidrug-resistant
Identifiants
pubmed: 32817379
pii: 5/4/e00525-20
doi: 10.1128/mSphere.00525-20
pmc: PMC7440845
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
IMP-8 enzyme
EC 3.5.2.-
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Peter et al.
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