In Vitro Cell Sensitivity to Palytoxin Correlates with High Gene Expression of the Na
Acrylamides
/ pharmacology
Adenosine Triphosphatases
/ genetics
Adult
Cation Transport Proteins
/ genetics
Cell Adhesion Molecules, Neuronal
/ genetics
Cnidarian Venoms
/ pharmacology
Female
Gene Expression Regulation
/ drug effects
Humans
Male
Middle Aged
Monocytes
/ drug effects
Protein Isoforms
/ genetics
Protein Subunits
/ genetics
Na+/K+-ATPase
cytotoxicity
genetic variants
palytoxin
toxicogenetic
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Aug 2020
14 Aug 2020
Historique:
received:
08
07
2020
revised:
03
08
2020
accepted:
13
08
2020
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
20
2
2021
Statut:
epublish
Résumé
The marine polyether palytoxin (PLTX) is one of the most toxic natural compounds, and is involved in human poisonings after oral, inhalation, skin and/or ocular exposure. Epidemiological and molecular evidence suggest different inter-individual sensitivities to its toxic effects, possibly related to genetic-dependent differences in the expression of Na
Identifiants
pubmed: 32823835
pii: ijms21165833
doi: 10.3390/ijms21165833
pmc: PMC7461505
pii:
doi:
Substances chimiques
ATP1B2 protein, human
0
Acrylamides
0
Cation Transport Proteins
0
Cell Adhesion Molecules, Neuronal
0
Cnidarian Venoms
0
Protein Isoforms
0
Protein Subunits
0
Adenosine Triphosphatases
EC 3.6.1.-
palytoxin
OQ17NC0MOV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Università degli Studi di Trieste
ID : FRA2018
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