Differential Labeling of Glycoproteins with Alkynyl Fucose Analogs.
click chemistry
fucose
fucosyltransferase
glycan
glycan labeling
glycosylation
notch
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Aug 2020
20 Aug 2020
Historique:
received:
29
07
2020
revised:
12
08
2020
accepted:
18
08
2020
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
14
4
2021
Statut:
epublish
Résumé
Fucosylated glycans critically regulate the physiological functions of proteins and cells. Alterations in levels of fucosylated glycans are associated with various diseases. For detection and functional modulation of fucosylated glycans, chemical biology approaches using fucose (Fuc) analogs are useful. However, little is known about how efficiently each unnatural Fuc analog is utilized by enzymes in the biosynthetic pathway of fucosylated glycans. We show here that three clickable Fuc analogs with similar but distinct structures labeled cellular glycans with different efficiency and protein specificity. For instance, 6-alkynyl (Alk)-Fuc modified
Identifiants
pubmed: 32825463
pii: ijms21176007
doi: 10.3390/ijms21176007
pmc: PMC7503990
pii:
doi:
Substances chimiques
Glycoproteins
0
Polysaccharides
0
Recombinant Proteins
0
Thrombospondin 1
0
thrombospondin-1, human
0
Guanosine Diphosphate
146-91-8
Fucose
28RYY2IV3F
Fucosyltransferases
EC 2.4.1.-
polypeptide fucosyltransferase
EC 2.4.1.221
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
EC 2.4.1.65
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Tokyo Biochemical Research Foundation
ID : YK
Organisme : NIGMS NIH HHS
ID : GM061126
Pays : United States
Organisme : Japan Society for the Promotion of Science
ID : JP19H03176
Organisme : Japan Society for the Promotion of Science
ID : 16811705
Organisme : Japan Agency for Medical Research and Development
ID : 16809274
Organisme : Takeda Science Foundation
ID : YK
Organisme : Japan Society for the Promotion of Science
ID : JP19H03416
Organisme : Japan Society for the Promotion of Science
ID : JP19KK0195
Organisme : Japan Society for the Promotion of Science
ID : JP20H03207
Organisme : NIGMS NIH HHS
ID : R01 GM061126
Pays : United States
Organisme : Takeda Science Foundation
ID : HT
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