Inhibition of Acetylcholinesterases by Stereoisomeric Organophosphorus Compounds Containing Both Thioester and
Journal
Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448
Informations de publication
Date de publication:
21 09 2020
21 09 2020
Historique:
pubmed:
25
8
2020
medline:
24
8
2021
entrez:
25
8
2020
Statut:
ppublish
Résumé
Studies with acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds with two chiral centers can serve as models or surrogates for understanding the rate, orientation, and postinhibitory mechanisms by the nerve agent soman that possesses dual phosphorus and carbon chiral centers. In the current approach, stereoisomers of
Identifiants
pubmed: 32833441
doi: 10.1021/acs.chemrestox.0c00236
doi:
Substances chimiques
Cholinesterase Inhibitors
0
Esters
0
Nitrophenols
0
Organophosphorus Compounds
0
Sulfhydryl Compounds
0
4-nitrophenyl acetate
830-03-5
Acetylcholinesterase
EC 3.1.1.7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2455-2466Subventions
Organisme : NINDS NIH HHS
ID : U01 NS092495
Pays : United States