Fibroblasts as a source of self-antigens for central immune tolerance.

Animals Autoantigens / immunology Autoimmunity Cells, Cultured Cellular Microenvironment Clonal Selection, Antigen-Mediated Dipeptidyl Peptidase 4 / metabolism Fibroblasts / immunology Immune Tolerance Lymphotoxin beta Receptor / genetics Membrane Glycoproteins / metabolism Mice Mice, Inbred C57BL Mice, Transgenic Receptors, Platelet-Derived Growth Factor / metabolism Signal Transduction T-Lymphocytes / immunology Thymus Gland / cytology

Journal

Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354

Informations de publication

Date de publication:
10 2020
Historique:
received: 05 11 2019
accepted: 02 07 2020
pubmed: 26 8 2020
medline: 7 1 2021
entrez: 26 8 2020
Statut: ppublish

Résumé

Fibroblasts are one of the most common but also neglected types of stromal cells, the heterogeneity of which underlies the specific function of tissue microenvironments in development and regeneration. In the thymus, autoreactive T cells are thought to be negatively selected by reference to the self-antigens expressed in medullary epithelial cells, but the contribution of other stromal cells to tolerance induction has been poorly examined. In the present study, we report a PDGFR

Identifiants

DOI: 10.1038/s41590-020-0756-8 PMID: 32839611
pubmed: 32839611
doi: 10.1038/s41590-020-0756-8
pii: 10.1038/s41590-020-0756-8
doi:

Substances chimiques

Autoantigens 0
Gp38 protein, mouse 0
Lymphotoxin beta Receptor 0
Membrane Glycoproteins 0
Receptors, Platelet-Derived Growth Factor EC 2.7.10.1
Dipeptidyl Peptidase 4 EC 3.4.14.5
Dpp4 protein, mouse EC 3.4.14.5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1172-1180

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Auteurs

Takeshi Nitta (T)

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan. nit-im@m.u-tokyo.ac.jp.
ORCID: 0000-0003-2384-3062

Masanori Tsutsumi (M)

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan.

Sachiko Nitta (S)

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan.

Ryunosuke Muro (R)

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan.

Emma C Suzuki (EC)

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan.

Kenta Nakano (K)

Department of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.

Yoshihiko Tomofuji (Y)

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan.

Shinichiro Sawa (S)

Division of Mucosal Immunology, Research Center for Systems Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
ORCID: 0000-0002-8850-446X

Tadashi Okamura (T)

Department of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.

Josef M Penninger (JM)

Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Life Science Institute, University of British Columbia, Vancouver, British Columbia, Canada.
ORCID: 0000-0002-8194-3777

Hiroshi Takayanagi (H)

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan. takayana@m.u-tokyo.ac.jp.
ORCID: 0000-0002-1462-4127

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Cellules › Cellules cultivées › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Sélection clonale médiée par un antigène › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Dipeptidyl peptidase 4 › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux facteurs de nécrose tumorale › Récepteur à la lymphotoxine-bêta › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance dérivés des plaquettes › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Fibroblasts as a source of self-antigens for...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Thymus (glande) › Fibroblasts as a source of self-antigens for...