Integrins α4β1 and αVβ3 are Reduced in Endothelial Progenitor Cells from Diabetic Dyslipidemic Mice and May Represent New Targets for Therapy in Aortic Valve Disease.
Animals
Aortic Valve Disease
Cells, Cultured
Diabetes Mellitus, Experimental
/ metabolism
Dyslipidemias
/ physiopathology
Endothelial Progenitor Cells
/ metabolism
Integrin alpha4beta1
/ metabolism
Integrin alphaVbeta3
/ metabolism
Male
Mice
Mice, Knockout
Stem Cells
/ metabolism
Streptozocin
/ therapeutic use
EPC
aortic valve
endothelial progenitor cells
integrins
recruitment
Journal
Cell transplantation
ISSN: 1555-3892
Titre abrégé: Cell Transplant
Pays: United States
ID NLM: 9208854
Informations de publication
Date de publication:
Historique:
entrez:
26
8
2020
pubmed:
26
8
2020
medline:
20
7
2021
Statut:
ppublish
Résumé
Diabetes reduces the number and induces dysfunction in circulating endothelial progenitor cells (EPCs) by mechanisms that are still uncovered. This study aims to evaluate the number, viability, phenotype, and function of EPCs in dyslipidemic mice with early diabetes mellitus and EPC infiltration in the aortic valve in order to identify possible therapeutic targets in diabetes-associated cardiovascular disease. A streptozotocin-induced diabetic apolipoprotein E knock-out
Identifiants
pubmed: 32841051
doi: 10.1177/0963689720946277
pmc: PMC7563030
doi:
Substances chimiques
Integrin alpha4beta1
0
Integrin alphaVbeta3
0
Streptozocin
5W494URQ81
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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