Oxidation-Specific Epitopes (OSEs) Dominate the B Cell Response in Murine Polymicrobial Sepsis.
Animals
Autoantibodies
/ immunology
Autoantigens
/ immunology
Autoimmunity
B-Lymphocytes
/ immunology
Biomarkers
Disease Models, Animal
Epitopes, B-Lymphocyte
/ genetics
Female
Immunodominant Epitopes
/ genetics
Immunoglobulin G
/ blood
Immunoglobulin M
/ blood
Immunohistochemistry
Mice
Mutation
Oxidation-Reduction
Sepsis
/ etiology
V(D)J Recombination
B cell response
CASP
oxidation-specific epitopes
polymicrobial sepsis
polyreactive antibodies
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
02
2020
accepted:
15
06
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
21
4
2021
Statut:
epublish
Résumé
In murine abdominal sepsis by colon ascendens stent peritonitis (CASP), a strong increase in serum IgM and IgG antibodies was observed, which reached maximum values 14 days following sepsis induction. The specificity of this antibody response was studied in serum and at the single cell level using a broad panel of bacterial, sepsis-unrelated as well as self-antigens. Whereas an antibacterial IgM/IgG response was rarely observed, studies at the single-cell level revealed that IgM antibodies, in particular, were largely polyreactive. Interestingly, at least 16% of the IgM mAbs and 20% of the IgG mAbs derived from post-septic mice showed specificity for oxidation-specific epitopes (OSEs), which are known targets of the innate/adaptive immune response. This identifies those self-antigens as the main target of B cell responses in sepsis.
Identifiants
pubmed: 32849533
doi: 10.3389/fimmu.2020.01570
pmc: PMC7412885
doi:
Substances chimiques
Autoantibodies
0
Autoantigens
0
Biomarkers
0
Epitopes, B-Lymphocyte
0
Immunodominant Epitopes
0
Immunoglobulin G
0
Immunoglobulin M
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1570Informations de copyright
Copyright © 2020 Nicolai, Pötschke, Raafat, van der Linde, Quosdorf, Laqua, Heidecke, Berek, Darisipudi, Binder and Bröker.
Références
Clin Vaccine Immunol. 2009 Nov;16(11):1607-14
pubmed: 19759252
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4542-6
pubmed: 17360560
Eur J Immunol. 1988 Feb;18(2):313-6
pubmed: 3350037
Nature. 1995 Apr 6;374(6522):546-9
pubmed: 7700380
J Leukoc Biol. 2008 Apr;83(4):1009-18
pubmed: 18211965
Nat Rev Immunol. 2010 Nov;10(11):778-86
pubmed: 20948548
Nat Rev Immunol. 2002 May;2(5):323-35
pubmed: 12033738
Shock. 2013 Jan;39(1):55-62
pubmed: 23247122
J Clin Invest. 1996 Aug 1;98(3):800-14
pubmed: 8698873
Nat Rev Immunol. 2011 Jan;11(1):34-46
pubmed: 21151033
J Leukoc Biol. 2007 Nov;82(5):1027-32
pubmed: 17615380
PLoS One. 2013 Nov 28;8(11):e81752
pubmed: 24312349
J Immunol. 1994 May 15;152(10):5014-21
pubmed: 8176219
Rev Neurol (Paris). 2019 Sep - Oct;175(7-8):420-426
pubmed: 31371185
J Immunol. 2007 Jun 15;178(12):7779-86
pubmed: 17548615
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
J Immunol. 2015 Feb 15;194(4):1609-20
pubmed: 25595784
J Immunol. 2010 Feb 1;184(3):1401-9
pubmed: 20026737
Front Immunol. 2018 Oct 31;9:2532
pubmed: 30429857
J Immunol. 1997 Feb 1;158(3):1175-86
pubmed: 9013957
J Immunol. 2001 Jun 1;166(11):6952-63
pubmed: 11359857
J Exp Med. 1974 Jan 1;139(1):74-92
pubmed: 4128449
Nat Rev Immunol. 2016 Aug;16(8):485-97
pubmed: 27346802
J Transl Med. 2010 Oct 14;8:97
pubmed: 20946647
Immunity. 2007 Feb;26(2):205-13
pubmed: 17306569
Immunol Rev. 2003 Aug;194:8-18
pubmed: 12846803
Eur J Immunol. 1999 Apr;29(4):1314-23
pubmed: 10229099
J Clin Invest. 2009 May;119(5):1335-49
pubmed: 19363291
EMBO J. 2013 Nov 13;32(22):2905-19
pubmed: 24002211
Infect Immun. 1998 May;66(5):2300-9
pubmed: 9573121
J Exp Med. 2011 Aug 1;208(8):1673-82
pubmed: 21746813
J Immunol. 2002 Mar 1;168(5):2493-500
pubmed: 11859143
Trends Immunol. 2018 Jul;39(7):515-522
pubmed: 29724608
Nat Rev Immunol. 2015 Mar;15(3):160-71
pubmed: 25698678
Immunol Rev. 2006 Jun;211:303-9
pubmed: 16824137
Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2030-8
pubmed: 25848033
Immunol Rev. 2012 May;247(1):52-63
pubmed: 22500831
Nat Rev Immunol. 2013 Feb;13(2):118-32
pubmed: 23348416
Front Immunol. 2020 Apr 30;11:828
pubmed: 32425951
J Immunol Methods. 2009 Oct 31;350(1-2):183-93
pubmed: 19716372
Science. 2003 Sep 5;301(5638):1374-7
pubmed: 12920303
J Immunol. 2015 Jan 1;194(1):13-20
pubmed: 25527792
J Exp Med. 2010 Nov 22;207(12):2767-78
pubmed: 21078890
Gut. 2008 Feb;57(2):188-95
pubmed: 17965062
Shock. 2015 Feb;43(2):192-200
pubmed: 25243429
Virologie. 1988 Jul-Sep;39(3):207-16
pubmed: 2848359
Eur J Immunol. 2012 Feb;42(2):341-52
pubmed: 22105154
Ann Transl Med. 2016 Sep;4(17):325
pubmed: 27713883
Front Immunol. 2017 Jul 13;8:775
pubmed: 28751890
J Exp Med. 2004 Dec 6;200(11):1359-70
pubmed: 15583011
N Engl J Med. 2013 Aug 29;369(9):840-51
pubmed: 23984731
J Immunol. 2003 Jul 15;171(2):909-14
pubmed: 12847261
Cent Eur J Immunol. 2018;43(4):466-475
pubmed: 30799995
J Exp Med. 1998 Dec 21;188(12):2381-6
pubmed: 9858525
Biochim Biophys Acta. 2012 Oct;1818(10):2465-75
pubmed: 22305963
Front Immunol. 2011 Dec 13;2:63
pubmed: 22566852
J Exp Med. 2006 Mar 20;203(3):553-61
pubmed: 16492804
Lancet. 2020 Jan 18;395(10219):200-211
pubmed: 31954465
Nat Med. 2003 Jun;9(6):736-43
pubmed: 12740573
BMJ Qual Saf. 2019 Sep;28(9):758-761
pubmed: 31018985
Nature. 2005 Nov 17;438(7066):364-8
pubmed: 16292312
Int Immunol. 2020 Jan 9;32(1):27-38
pubmed: 31504561
Immunol Rev. 1987 Apr;96:23-41
pubmed: 3298007
Shock. 2013 Jan;39(1):113-4
pubmed: 23247128
Ann N Y Acad Sci. 2015 Dec;1362:132-42
pubmed: 26104151
J Clin Immunol. 1994 Mar;14(2):134-40
pubmed: 8195315
Shock. 2004 Jun;21(6):505-11
pubmed: 15167678
Immunity. 2001 May;14(5):617-29
pubmed: 11371363
Front Neurol. 2019 Mar 15;10:221
pubmed: 30930837
Intensive Care Med. 2011 Jun;37(6):957-62
pubmed: 21359606
Circ Res. 2011 Jan 21;108(2):235-48
pubmed: 21252151