Body composition as reflected by intramuscular adipose tissue content may influence short- and long-term outcome following 2-stage liver resection for colorectal liver metastases.
Adipose Tissue
/ diagnostic imaging
Biomarkers
/ blood
Body Composition
Colorectal Neoplasms
/ pathology
Female
Hepatectomy
/ methods
Humans
Liver Neoplasms
/ mortality
Male
Middle Aged
Neoplasm Recurrence, Local
Nutritional Status
Postoperative Complications
Prognosis
Reoperation
Retrospective Studies
Survival Rate
Tomography, X-Ray Computed
2-stage hepatectomy
Body composition
Immunonutritional state
Intramuscular adipose tissue content
Journal
Langenbeck's archives of surgery
ISSN: 1435-2451
Titre abrégé: Langenbecks Arch Surg
Pays: Germany
ID NLM: 9808285
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
24
06
2020
accepted:
20
08
2020
pubmed:
28
8
2020
medline:
20
7
2021
entrez:
28
8
2020
Statut:
ppublish
Résumé
For many kinds of cancer, body composition and immunonutritional status have been reported to influence postoperative outcome. We assessed their impact on short- and long-term outcome in patients with colorectal liver metastases who underwent 2-stage liver resections. Short- and long-term outcomes for 47 patients with 2-stage hepatectomies were assessed retrospectively in terms of data obtained before preoperative chemotherapy, before the first hepatectomy, and before the second hepatectomy. Although immunonutritional status and body composition did not affect short-term outcome, high intramuscular fat content before the second hepatectomy was a poor prognostic factor for overall survival (HR, 5.829; 95% CI, 1.611-21.090; p = 0.007) and for recurrence-free survival (HR, 2.787; 95% CI, 1.301-5.973; p = 0.008). Patients with high intramuscular fat before the second hepatectomy also showed shorter intervals from recurrence to treatment failure. Intramuscular fat before the second hepatectomy is an important negative prognosticator in 2-stage liver resection for colorectal liver metastases.
Identifiants
pubmed: 32851433
doi: 10.1007/s00423-020-01973-1
pii: 10.1007/s00423-020-01973-1
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
757-766Références
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