The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis.
Alarmins
Gait analysis
Incapacitance
Nociception
Pain
S100A8
S100A9
Sensitization
Synovitis
TLR4
Journal
Arthritis research & therapy
ISSN: 1478-6362
Titre abrégé: Arthritis Res Ther
Pays: England
ID NLM: 101154438
Informations de publication
Date de publication:
27 08 2020
27 08 2020
Historique:
received:
23
03
2020
accepted:
17
08
2020
entrez:
29
8
2020
pubmed:
29
8
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Synovitis-associated pain is mediated by inflammatory factors that may include S100A8/9, which is able to stimulate nociceptive neurons via Toll-like receptor 4. In this study, we investigated the role of S100A9 in pain response during acute synovitis. Acute synovitis was induced by streptococcal cell wall (SCW) injection in the knee joint of C57Bl/6 (WT) and S100A9 Intra-articular SCW injection resulted in increased synovial expression and serum levels of S100A8/A9 at day 1. These increased levels, however, did not contribute to the development of inflammation, since this was equal in S100A9 S100A8/9, released from the synovium upon inflammation, is an important mediator of pain response in the knee during the acute phase of inflammation.
Sections du résumé
BACKGROUND
Synovitis-associated pain is mediated by inflammatory factors that may include S100A8/9, which is able to stimulate nociceptive neurons via Toll-like receptor 4. In this study, we investigated the role of S100A9 in pain response during acute synovitis.
METHODS
Acute synovitis was induced by streptococcal cell wall (SCW) injection in the knee joint of C57Bl/6 (WT) and S100A9
RESULTS
Intra-articular SCW injection resulted in increased synovial expression and serum levels of S100A8/A9 at day 1. These increased levels, however, did not contribute to the development of inflammation, since this was equal in S100A9
CONCLUSIONS
S100A8/9, released from the synovium upon inflammation, is an important mediator of pain response in the knee during the acute phase of inflammation.
Identifiants
pubmed: 32854769
doi: 10.1186/s13075-020-02295-9
pii: 10.1186/s13075-020-02295-9
pmc: PMC7457270
doi:
Substances chimiques
Alarmins
0
Calgranulin A
0
Calgranulin B
0
S100A9 protein, mouse
0
S100a8 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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