Cognitive reserve and midlife vascular risk: Cognitive and clinical outcomes.
Aged
Cerebral Small Vessel Diseases
/ diagnostic imaging
Cognitive Dysfunction
/ diagnosis
Cognitive Reserve
/ physiology
Comorbidity
Disease Progression
Educational Status
Executive Function
/ physiology
Female
Heart Disease Risk Factors
Humans
Leukoaraiosis
/ diagnostic imaging
Longitudinal Studies
Magnetic Resonance Imaging
Male
Memory, Episodic
Middle Aged
Reading
Vocabulary
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
11
02
2020
revised:
18
05
2020
accepted:
05
06
2020
entrez:
29
8
2020
pubmed:
29
8
2020
medline:
18
8
2021
Statut:
ppublish
Résumé
Examine whether cognitive reserve moderates the association of 1) vascular risk factors and 2) white matter hyperintensity burden with risk of clinical progression and longitudinal cognitive decline. BIOCARD Study participants were cognitively normal and primarily middle-aged (M = 57 years) at baseline and have been followed with annual cognitive and clinical assessments (M = 13 years). Baseline cognitive reserve was indexed with a composite score combining education with reading and vocabulary scores. Baseline vascular risk (N = 229) was assessed with a composite risk score reflecting five vascular risk factors. Baseline white matter hyperintensity load (N = 271) was measured with FLAIR magnetic resonance imaging. Cox regression models assessed risk of progression from normal cognition to onset of clinical symptoms of Mild Cognitive Impairment. Longitudinal mixed effects models measured the relationship of these variables to cognitive decline, using a global composite score, and executive function and episodic memory sub-scores. Both vascular risk and white matter hyperintensities were associated with cognitive decline, particularly in executive function. Higher vascular risk, but not white matter hyperintensity burden, was associated with an increased risk of progression to Mild Cognitive Impairment. Higher cognitive reserve was associated with a reduced risk of symptom onset and higher levels of baseline cognition but did not modify the associations between the vascular risk score and white matter hyperintensities with clinical progression or cognitive decline. Although cognitive reserve has protective effects on clinical and cognitive outcomes, it does not mitigate the negative impact of vascular risk and small vessel cerebrovascular disease on these same outcomes.
Identifiants
pubmed: 32856790
doi: 10.1002/acn3.51120
pmc: PMC7448143
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1307-1317Subventions
Organisme : NIA NIH HHS
ID : U19 AG033655
Pays : United States
Organisme : NIH HHS
ID : P50-AG005146
Pays : United States
Organisme : NIH HHS
ID : U19-AG033655
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NIH HHS
ID : K24-AG052573
Pays : United States
Informations de copyright
© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
Références
Dement Geriatr Cogn Disord. 2016;42(1-2):117-26
pubmed: 27632695
Neurology. 2013 Jul 9;81(2):126-33
pubmed: 23761624
J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):848-54
pubmed: 18772473
Alzheimers Dement. 2018 Feb;14(2):167-177
pubmed: 28916238
Neurobiol Aging. 2020 Apr;88:33-41
pubmed: 31932050
Neurology. 2020 Mar 3;94(9):e950-e960
pubmed: 31888969
Hypertension. 2004 Nov;44(5):625-30
pubmed: 15466662
JAMA. 2017 Apr 11;317(14):1443-1450
pubmed: 28399252
Neurobiol Aging. 2013 Dec;34(12):2827-34
pubmed: 23916061
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2017 May;24(3):256-263
pubmed: 27302740
Neurology. 2003 Mar 11;60(5):831-6
pubmed: 12629242
Alzheimer Dis Assoc Disord. 2015 Jan-Mar;29(1):18-25
pubmed: 24787033
Neurology. 2019 Feb 19;92(8):e823-e830
pubmed: 30674592
JAMA. 2018 Aug 21;320(7):665-673
pubmed: 30140877
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
JAMA Neurol. 2014 Oct;71(10):1218-27
pubmed: 25090106
JAMA Neurol. 2020 Mar 1;77(3):350-357
pubmed: 31860001
Dement Geriatr Cogn Disord. 2017;44(1-2):84-91
pubmed: 28743108
Ann Clin Transl Neurol. 2016 Sep 01;3(10):791-800
pubmed: 27752514
Biometrics. 1993 Mar;49(1):1-11
pubmed: 8513095
Brain. 2015 Mar;138(Pt 3):761-71
pubmed: 25595145
Neurobiol Aging. 2015 Apr;36(4):1670-1677
pubmed: 25666995
Am J Geriatr Psychiatry. 2009 Mar;17(3):218-26
pubmed: 19454848
Biometrics. 1982 Dec;38(4):963-74
pubmed: 7168798
Neurology. 2011 May 31;76(22):1879-85
pubmed: 21543737
Science. 1993 Aug 13;261(5123):921-3
pubmed: 8346443
J Women Aging. 2019 Mar-Apr;31(2):140-164
pubmed: 29319430
Curr Alzheimer Res. 2014;11(8):773-84
pubmed: 25212916
Neurobiol Aging. 2011 Sep;32(9):1588-98
pubmed: 19926168
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2006 Sep-Dec;13(3-4):326-40
pubmed: 16887777
J Int Neuropsychol Soc. 2011 May;17(3):531-6
pubmed: 21385518
J Aging Health. 2018 Sep;30(8):1171-1187
pubmed: 28553824
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2013;20(6):684-99
pubmed: 23339557
J Nutr Health Aging. 2015 Feb;19(2):183-9
pubmed: 25651444
Neurology. 2014 Jun 10;82(23):2127-38
pubmed: 24814849
Curr Neurol Neurosci Rep. 2019 Jan 9;19(1):1
pubmed: 30627880
Alzheimers Dement. 2009 May;5(3):207-14
pubmed: 19362884
Nat Genet. 1994 Jun;7(2):180-4
pubmed: 7920638
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2016;23(2):253-62
pubmed: 26667889
BMJ. 2001 Jun 16;322(7300):1447-51
pubmed: 11408299
Stroke. 2010 Jan;41(1):3-8
pubmed: 19926835
Ann Intern Med. 2019 Sep 17;171(6):389-396
pubmed: 31450238
J Alzheimers Dis. 2014;42(4):1295-310
pubmed: 25024338
Stroke. 2008 Oct;39(10):2712-9
pubmed: 18635849
Alzheimers Dement. 2020 Sep;16(9):1305-1311
pubmed: 30222945
BMC Med. 2014 Nov 11;12:206
pubmed: 25385447
Ann Neurol. 2020 Jan;87(1):52-62
pubmed: 31721283
Brain. 2005 Sep;128(Pt 9):2034-41
pubmed: 15947059
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
J Neurol Neurosurg Psychiatry. 2016 Dec;87(12):1296-1302
pubmed: 27951523
Am J Geriatr Psychiatry. 2014 Nov;22(11):1336-45
pubmed: 24021219
Neurology. 2011 Aug 2;77(5):461-8
pubmed: 21810696