Increasing incidence of acute autoimmune hepatitis: a nationwide survey in Japan.
Acute Disease
Adult
Aged
Alanine Transaminase
/ analysis
Antibodies, Antinuclear
/ analysis
Bilirubin
/ analysis
Female
Hepatitis, Autoimmune
/ diagnosis
Humans
Immunoglobulin G
/ analysis
Incidence
Japan
/ epidemiology
Liver
/ pathology
Male
Middle Aged
Prednisolone
/ therapeutic use
Surveys and Questionnaires
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 08 2020
28 08 2020
Historique:
received:
23
01
2020
accepted:
13
08
2020
entrez:
30
8
2020
pubmed:
30
8
2020
medline:
13
1
2021
Statut:
epublish
Résumé
The Japanese diagnostic guidelines for autoimmune hepatitis (AIH) were proposed in 2014. This study aimed to determine the trends and characteristics of AIH based on a Japanese nationwide survey. Data for 796 patients who were newly diagnosed with AIH from 2014 to 2017 were collected from January to March, 2019 from 54 hospitals throughout Japan. Clinical characteristics, including treatment, were compared with those reported in a prior 2015 survey. The population had a median age of 63 years at diagnosis, and the male to female ratio was 1:5.3. The numbers of women was significantly lower in this survey than in the 2015 survey. Moreover, the incidence of AIH with histological acute hepatitis increased significantly from 11.0 to 21.7%. The changes in the laboratory findings, such as in transaminase and immunoglobulin G levels and antinuclear antibody titers, as well as in prednisolone treatment, reflected an increasing incidence of acute AIH. The clinical characteristics of AIH changed rapidly, in parallel with the increasing incidence of acute AIH. The elucidation and diagnosis of AIH with acute hepatitis are important in the management of AIH.
Identifiants
pubmed: 32859968
doi: 10.1038/s41598-020-71296-0
pii: 10.1038/s41598-020-71296-0
pmc: PMC7455563
doi:
Substances chimiques
Antibodies, Antinuclear
0
Immunoglobulin G
0
Prednisolone
9PHQ9Y1OLM
Alanine Transaminase
EC 2.6.1.2
Bilirubin
RFM9X3LJ49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14250Références
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