Oxytocin Receptor Gene (OXTR) and Childhood Adversity Influence Trust.
OXTR rs53576
caution
childhood adversity
general trust
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
03
04
2020
revised:
27
06
2020
accepted:
12
08
2020
pubmed:
1
9
2020
medline:
25
8
2021
entrez:
1
9
2020
Statut:
ppublish
Résumé
Early-life environments have been associated with various social behaviors, including trust, in late adolescence and adulthood. Given that the oxytocin receptor gene polymorphism (OXTR rs53576) moderates the impact of childhood experience on social behaviors, in the present study, we examined the main effect of childhood adversity through a self-report measure and its interactions with OXTR rs53576 on general trust among 203 Japanese and 200 European Canadian undergraduate students. After controlling for the effect of culture, the results indicated that childhood adversity had a negative association with general trust, and that OXTR rs53576 moderated the impact of childhood adversity on general trust. Specifically, the negative association between childhood adversity and general trust is only significant among homozygote A-allele carriers. These findings demonstrated that OXTR rs53576 moderated the relations between childhood experiences and social functioning in early adulthood.
Identifiants
pubmed: 32866773
pii: S0306-4530(20)30262-6
doi: 10.1016/j.psyneuen.2020.104840
pii:
doi:
Substances chimiques
OXTR protein, human
0
Receptors, Oxytocin
0
Oxytocin
50-56-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104840Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.